Dr. Edward Allan Sison, a former St. Baldrick’s Fellow, is a faculty member at Baylor College of Medicine and Texas Children’s Cancer Center. He’s researching ways to make chemotherapy more effective in children with high-risk leukemias. He explains APL leukemia symptoms, treatment options, and how your support is moving research forward to help kids with this disease.
What is acute promyelocytic leukemia?
Leukemia is a cancer of the white blood cells. Acute promyelocytic leukemia (APL) comes from a type of white blood cells called promyelocytes.
Normal promyelocytes will grow up into white blood cells that fight off infection. In APL, the promyelocytes forget that they are supposed to grow up, and instead multiply at a very fast rate.
Dr. Gordon Cohen is a St. Baldrick’s Fellow at the John Hopkins Children’s Center. He’s testing new drugs for patients with Ph+ALL who relapse or fail to respond to treatment. He explains Ph+ALL symptoms, treatment options, and how your support is moving clinical trials forward to help kids with this disease.
What is Ph+ALL?
Philadelphia Chromosome positive acute lymphoblastic leukemia (Ph+ALL) is a rare subtype of the most common childhood cancer, acute lymphoblastic leukemia (ALL).
Dr. Carlos Rodriguez-Galindo is a St. Baldrick’s researcher at St. Jude Children’s Research Hospital and a member of the St. Baldrick’s Scientific Advisory Committee. He explains what Langerhans cell hystiocytosis is, how it’s diagnosed and treated, and how research is helping kids and adults with this disease.
What is Langerhans cell hystiocytosis?
Langerhans cell hystiocytosis, often called LCH, is a disorder where the body produces too many Langerhans cells.
A Langerhans cell is a type of white blood cell that normally helps the body fight off infection. In LCH, the body produces too many of these cells. The cells build up in the body, sometimes damaging organs or forming tumors.
What is DIPG?
DIPG stands for diffuse intrinsic pontine glioma. It is a type of high-grade glioma, a brain tumor that comes from cells called glia that surround, protect, and otherwise support the nerve cells in the brain.
DIPG is always found in the brainstem. This part of the brain controls many basic functions like breathing and swallowing, as well as muscles that help with speech and eye movements.
It is most common in elementary school-aged children, but it can affect children of any age.
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About 250 kids in the U.S. are diagnosed with DIPG each year.
Dr. Elliot Stieglitz is a St. Baldrick’s Fellow at the University of California, San Francisco. He’s researching ways to help kids with JMML who don’t respond to standard treatment. He explains JMML symptoms, treatment options, and how your support is moving research forward.
What is JMML?
Juvenile myelomonocytic leukemia (JMML) is a type of blood cancer that affects young children.
Dr. Jeffrey Toretsky is a St. Baldrick’s researcher at the Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C. He explains what sarcoma is, how it’s diagnosed and treated, and how research is helping kids and adults with this type of cancer.
What is sarcoma?
A sarcoma is a bumpy tumor that occurs in the connective tissues (nerves, muscles and bones) anywhere in the body.
Sarcomas are rare, especially in young children. In kids between 10 and 20, sarcomas make up about 20-25% of childhood cancer diagnoses.
Sarcomas can start off being tiny lumps that you can’t feel. They can spread through the body, or metastasize, before they grow big enough to be seen.
What is neuroblastoma?
Neuroblastoma is a type of childhood cancer that develops in nerve tissue outside of the central nervous system. It usually begins in the adrenal gland on top of the kidney, but it can be found anywhere along the spine.
What is acute lymphoblastic leukemia?
Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells that normally fight infection. The cells do not grow and develop properly, filling up the bone marrow inside bones, where blood is normally made.
ALL is the most common type of childhood cancer, accounting for 35% of all cancers in children. Each year, there are about 2,900 new cases of children and adolescents diagnosed with ALL in the United States alone.
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Its signs and symptoms resemble other common illnesses, which often leads to other treatments before the leukemia diagnosis is made.
What is Wilms tumor?
Wilms tumor is a cancer of the kidney. It is one of the most common types of childhood cancer, with approximately 500 new patients a year in the United States alone.
Dr. Matthew Barth is a St. Baldrick’s Scholar at the University of Buffalo in Buffalo, New York. He is studying ways to help kids with non-Hodgkin lymphoma who don’t respond to treatment.
What is non-Hodgkin lymphoma?
Non-Hodgkin lymphoma is a cancer of white blood cells called lymphocytes. Non-Hodgkin lymphoma generally involves the lymph nodes, but can also involve many other organs, including the bones, bone marrow, liver, spleen, brain and skin.
There are many types of non-Hodgkin lymphoma. Children tend to have more aggressive forms of the disease, while adults frequently have less aggressive forms. Non-Hodgkin lymphoma is very rare in children younger than 3 years old and is seen more often in adolescents.
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