Research Outcomes: Building Hope
This research is powered by you. This quarterly edition of the St. Baldrick’s Foundation Research Outcomes recognizes promising research to improve survival rates, provide holistic therapies, and translate adult drugs into pediatric trials.
Thank you for making research possible.
Using Precision Medicine to Improve Pediatric Cancer Treatment
EXCITING UPDATE November 1, 2022: The largest academic collaboration of its kind was announced last month, and it builds off this St. Baldrick’s supported work. The Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute and St. Jude Children’s Research Hospital will collaborate to transform and accelerate the identification of vulnerabilities in pediatric cancers and translate them into better treatments.
Dr. Stegmaier said, “The Pediatric Cancer Dependency Map provided our community with a treasure trove of new data. However, the next critical step was to validate candidate gene targets emerging from this project. The St. Baldrick’s Foundation Robert J Arceci Innovation Award provided the critical funding for us to demonstrate the power of the Pediatric Cancer Dependency Map.
With St. Baldrick’s support, we validated new candidate therapeutic targets in childhood cancers, such as Ewing sarcoma and neuroblastoma, which have led to the launching of drug discovery efforts, and we have gained novel insights into the mechanistic underpinnings of these diseases. We were able to show our community the power of the project. I think we are just at the tip of the iceberg. We are all very excited about the promise of what is to come through this new large-scale collaboration.”
We are excited to see the impact this collaboration has in helping to conquer childhood cancer.
Update: More Hope for Children with Cancer in Africa
Of the many incredible things St. Baldrick’s donors have made possible for kids with cancer, one stands out to me like no other. The return on investment from this one grant has already far exceeded expectations, and each year its impact continues to grow.
A Seed Planted
With the goal of training doctors from low- and middle-income countries, the first St. Baldrick’s International Scholar was awarded in 2013. But while Dr. Joseph Lubega of Uganda was in training at Baylor College of Medicine in Houston, he was also planting a seed: He set up the first pediatric oncology program for pediatricians in his home country.
With St. Baldrick’s support, Dr. Lubega became one of the first trained pediatric oncologists in all of Uganda, where the need is great – as it is across Africa.
Research Outcomes: Your Dollars at Work
Read on to learn about some of the research that – thanks to you – is changing the world of childhood cancer care.
Q&A On Fertility After Adolescent or Young Adult Cancer
Each survivor’s risk of late effects of cancer treatment depends on their tumor, specific treatments, age, genetic makeup and other factors. Surgeries, chemotherapies, radiation, stem cell transplants and other treatments take a toll on the body – and sometimes the mind – in many ways. Some late effects make life more difficult; others are life-threatening.
Heart and lung problems are common, as are secondary cancers.
Other late effects can include hearing problems, hormonal imbalances, difficulty growing, mental health needs or cognitive deficiencies, bone density issues and easy bone fractures, fertility and reproductive problems, and more.
Research Outcomes: Incredible Impact and Hope
Formerly known as the St. Baldrick’s – Stand Up to Cancer Pediatric Cancer Dream Team, this team is now the St. Baldrick’s EPICC Team (Empowering Pediatric Immunotherapies for Childhood Cancer).
Your generosity makes a difference for children and young adults with cancer. Read on to see a few recent examples of the incredible impact you have on pediatric cancer research.
Rolling Up Their Lab Coat Sleeves: The 2022 St. Baldrick’s Fellows
The next generation of childhood cancer researchers is rolling up their lab coat sleeves and doubling down on the fight to end childhood cancers.
Thanks to donors like you, these doctors will train with leaders in the field and launch new research projects to answer pressing questions in the quest to conquer childhood cancers.
Explore the new research you’re supporting:
Research Outcomes: Novel Discoveries
Scientific research continues at a great pace thanks to your tireless support. Pediatric cancer researchers proceed to make new discoveries and provide hope for children with cancer. See five examples of the many research outcomes you’ve made possible below:
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