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Grzegorz Nalepa M.D., Ph.D.

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Funded: 07-01-2016 through 06-30-2019
Funding Type: St. Baldrick's Scholar
Institution Location: Indianapolis, IN
Institution: Indiana University affiliated with Riley Hospital for Children, IU Health Proton Therapy Center

Children continue to die from leukemia because malignant cells overcome chemotherapy by turning off normal genetic safety checkpoints. Dr. Nalepa has found that loss of the same checkpoints makes cancer growth dependent on other genes, which represent possible anti-cancer targets. Dr. Nalepa is investigating the weak points of the cancer cells, and testing these precision-medicine strategies in new models of childhood leukemia. Dr. Nalepa will use the results of this testing to generate personalized therapy driven by cancer-specific mutations that will be more effective and less toxic for children who suffer from leukemia.

Elizabeth Stewart M.D.

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Funded: 07-01-2016 through 06-30-2019
Funding Type: St. Baldrick's Scholar
Institution Location: Memphis, TN
Institution: St. Jude Children's Research Hospital

Pediatric cancer patients that have high-risk solid tumors can be very difficult to treat, particularly when their cancer has come back after previous treatment or has spread to multiple areas of the body. Dr. Stewart is looking for specific mutations in the tumors of these patients, and testing new cancer drugs to customize treatment to give patients with relapsed high-risk solid tumors with better treatment options.

This grant is made with generous support from the Invictus Fund, a St. Baldricks's Hero Fund which was created in memory of Holden Gilkinson. It honors Holden's unconquerable spirit in his battle with bilateral Wilms tumor by funding cures and treatments to mitigate side and late effects of childhood cancer.

Elias Sayour M.D., Ph.D.

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Funded: 07-01-2016 through 12-31-2020
Funding Type: St. Baldrick's Scholar
Institution Location: Gainesville, FL
Institution: University of Florida affiliated with Shands Hospital for Children

Based on progress to date, Dr. Sayour was awarded a new grant in 2019 to fund an additional year of this Scholar grant. For children affected by medulloblastoma, the development of more effective and specific therapies that will not add further toxicity to existing treatments is critical in improving clinical outcomes. Dr. Sayour, the Hannah's Heroes St. Baldrick's Scholar, is investigating methods to harness the immune system to destroy these tumors though the use of nanoparticle vaccines. Nanoparticles can deliver messages to the immune system teaching it to kill cancer cells. Dr. Sayour is studying possible immune targets for nanoparticles in medulloblastoma, identifying underlying tumor resistance mechanisms, and establishing an optimum vaccine approach which he will evaluate in medulloblastoma models.

This grant is named for Hannah's Heroes, a St. Baldrick's Hero Fund created in honor of Hannah Meeson and pays tribute to her fight by raising awareness and funding for all childhood cancers.

Dhvanit Shah Ph.D.

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Funded: 07-01-2016 through 06-30-2020
Funding Type: St. Baldrick's Scholar
Institution Location: Columbus, OH
Institution: Nationwide Children's Hospital affiliated with The Research Institute at Nationwide

Based on progress to date, Dr. Shah was awarded a new grant in 2019 to fund an additional year of this Scholar grant. Finding a donor for a bone marrow transplant can be difficult for patients that are mixed-race or from an ethnic minority, as bone-marrow comes from donors that are genetically compatible. Dr. Shah is developing a method utilizing hemogenic endothelial cells (HEC) that will have the same effect, without requiring bone marrow from a matched donor. Dr. Shah is investigating FDA-approved drugs that stimulate the HECs to produce a novel and safe alternative to bone marrow-generated Hematopoietic stem cells, which will potentially treat childhood blood cancers. Awarded at the Brigham and Women's Hospital and transferred to Nationwide Children's Hospital.

University of Hawaii Summer Fellow

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Funded: 07-01-2016 through 06-30-2017
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Honolulu, HI
Institution: University of Hawaii Cancer Center

This grant funds a student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Yale School of Medicine Summer Fellow

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Funded: 07-01-2016 through 08-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: New Haven, CT
Institution: Yale University affiliated with Yale-New Haven Children's Hospital

This grant funds a doctoral student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

The Jackson Laboratory Summer Fellow

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Funded: 06-12-2016 through 08-12-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Bar Harbor, ME
Institution: The Jackson Laboratory

This grant funds a medical student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Weill Cornell Medical College Summer Fellow

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Funded: 06-08-2016 through 08-03-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: New York, NY
Institution: Weill Medical College of Cornell University affiliated with Weill Cornell Medical Center, New York-Presbyterian

This grant funds a medical student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

University of Wisconsin-Madison Summer Fellow

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Funded: 06-06-2016 through 08-19-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Madison, WI
Institution: University of Wisconsin-Madison affiliated with American Family Children's Hospital

This grant funds a doctoral student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

State University of New York at Stony Brook Summer Fellow

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Funded: 06-06-2016 through 08-08-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Stony Brook, NY
Institution: Stony Brook University affiliated with Stony Brook Long Island Children's Hospital

This grant funds a student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Medical College of Wisconsin Summer Fellow

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Funded: 06-01-2016 through 12-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Milwaukee, WI
Institution: Medical College of Wisconsin affiliated with Midwest Children's Cancer Center, Children's Hospital of Wisconsin

This grant funds a medical student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Virginia Polytechnic Institute and State University Summer Fellow

Funded: 06-01-2016 through 08-21-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Blacksburg, VA
Institution: Virginia Polytechnic Institute and State University

This grant funds a medical student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Duke University Summer Fellow

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Funded: 06-01-2016 through 07-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Durham, NC
Institution: Duke University Medical Center affiliated with Duke Children's Hospital & Health Center

This grant funds an undergraduate student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Washington University in St. Louis Summer Fellow

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Funded: 06-01-2016 through 07-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: St. Louis, MO
Institution: Washington University in St. Louis affiliated with St. Louis Children's Hospital

This grant funds an undergraduate student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

University of Minnesota Summer Fellow

Funded: 06-01-2016 through 08-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Minneapolis, MN
Institution: University of Minnesota - Twin Cities affiliated with Masonic Children's Hospital

This grant funds a student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

University of California Berkeley Summer Fellow

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Funded: 06-01-2016 through 08-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Berkeley, CA
Institution: University of California, Berkeley

This grant funds a doctoral student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Case Western Reserve University Summer Fellow

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Funded: 05-31-2016 through 08-05-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Cleveland, OH
Institution: Case Western Reserve University

This grant funds two students to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Children's Hospital Los Angeles Summer Fellow

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Funded: 05-25-2016 through 08-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Los Angeles, CA
Institution: Children's Hospital Los Angeles

This grant funds two students to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

University of Illinois Chicago Summer Fellow

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Funded: 05-23-2016 through 05-22-2017
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Chicago, IL
Institution: University of Illinois - Chicago affiliated with University Of Illinois Hospital & Health Sciences System

This grant funds two medical students to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.

Medical University of South Carolina Summer Fellow

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Funded: 05-16-2016 through 08-12-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: Charleston, SC
Institution: Medical University of South Carolina affiliated with MUSC Children's Hospital

This grant funds a student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.