Grants Search Results

Ewing Sarcoma (EwS) is an aggressive bone and soft tissue tumor occurring in children and young adults. Approximately 25-30% of patients already have metastases at diagnosis and in spite of aggressive treatment, the survival for patients with metastatic disease remains dismal. EwS is considered an immune cold tumor that is largely resistant to conventional immunotherapy. Alternative treatment approaches are sorely needed, particularly in patients with metastatic disease. Dr. Sorensen and colleagues are using three novel strategies for targeting EwS tumors: 1) Inhibiting an EwS specific fusion protein that drives EwS tumor development. 2) Targeting a surface protein called IL1RAP. 3) Recruiting natural killer (NK) immune cells to EwS tumors and priming them to attack the tumor. This grant is the result of a generous anonymous donation to fund Ewing sarcoma research, specifically. It is in honor of a teenager fighting Ewing sarcoma, and is named the St. Baldrick's - Martha's Better Ewing Sarcoma Treatment (BEST) Grant for All.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Integrative oncology is a patient-centered, evidence-informed field of cancer care that uses mind and body practices, natural products, and lifestyle modifications from various traditions alongside traditional cancer treatments. Many complementary and alternative medicine approaches have been shown to improve symptom control and quality of life for patients and survivors. The field of integrative oncology has emerged in recent years as interest in and the use of these therapies have grown. The goal of this scientific discipline is to combine evidence-based complementary medicine and traditional cancer treatment to address the diverse needs of patients with cancer and their families. This grant supports an Integrative and Supportive Care Oncology Coordinator to ensure that more kids can be treated on supportive care and integrative oncology clinical trials.

This grant supports a research coordinator to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a bilingual Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a clinical research nurse to ensure that more kids can be treated on early phase clinical trials, often their best hope for a cure.

This grant supports a pediatric solid tumor program Clinical Research Associate to ensure that more solid tumor patients can be treated on clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Over 80% of children treated for childhood cancers will become long term survivors. With this success in survival comes the challenge of caring for survivors and their unique long term follow up needs. As late effects of childhood cancer treatment are continuing to be described, it is essential that survivors are enrolled on clinical trials that monitor outcomes to inform late effects guidelines. In addition, more emphasis is being placed on intervention trials for survivors which are critically important in increasing survivors' access to state of the art interventions as well as increasing knowledge about how best to help the survivor population. This grant supports a dedicated Survivorship Clinical Research Associate to ensure that more survivors of childhood cancer can have access to clinical trials targeted at the survivorship population.

Young adulthood is a time filled with exciting possibilities and also difficult challenges. People at this stage of life may be deciding on or attending school, selecting a career or working hard at their jobs, dating or in a relationship, and may be planning for or raising children. A cancer diagnosis does not fit into these plans and goals. Researchers are finding that the biology of the cancers in people of this age group are different, and increasing data indicates that adult patients with some cancers would benefit by being treated on what are traditionally pediatric therapies. Ochsner's Adolescent and Young Adult (AYA) Cancer and Survivor program is the first and only one of its kind in the region. The team is made up of professionals from pediatric and adult medicine. This program is designed for people between the ages of 15 and 39 years of age with cancer -newly diagnosed, actively in therapy and or cancer survivors. This grant supports a Nurse Coordinator who works with new patients in the combined AYA Cancer and Survivor Clinic, to ensure they have access to the best clinical trials for their cancer.

This grant supports a clinical research coordinator to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on immunotherapy clinical trials, often their best hope for a cure.

This grant supports a solid tumor research coordinator to ensure that more solid tumor patients can be treated on early phase clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Imaging presents a powerful tool by visualizing individual cells and cellular processes in great detail. However, it remains very challenging to obtain this detailed cellular information for entire tumors and surrounding tissue, which will be key for improving our understanding of cancer progression. To fulfil this need, Dr. Rios and colleagues have developed unique and innovative imaging strategies that can visualize individual cells and their specific behavior in an entire tissue or tumor specimen. She is applying this advanced three-dimensional (3D) imaging to study the underlying mechanisms of childhood cancer. For instance, they have been able to identify new tumor cell subsets that are now being analyzed for their role in tumor progression. In addition, she is studying the specific behavior and underlying mechanisms that allow tumor cells to invade their surrounding tissue, a key contributing factor to tumor aggressiveness. By applying these imaging technologies to address these and other unanswered questions in pediatric oncology, Dr. Rios hopes to identify novel targets for treating childhood cancer. The St. Baldrick’s Robert J. Arceci Innovation Award is given in honor of the late Dr. Robert Arceci. A pioneer in the field, this award reflects Dr. Arceci’s values including creativity, collaboration, and commitment to early- to mid-career scientists.

Through this partnership with The Children's Cancer Foundation, proceeds from St. Baldrick's events in Hong Kong fund life-saving research in Hong Kong. The St. Baldrick's Foundation is proud to partner with the Children's Cancer Foundation and has been doing so since 2008.

This grant funded three projects. Project 1: A five-year study on Paediatric Hepatic International Tumour Trial (PHITT) in Hong Kong. Project 2: An extension of a parallel study with the Chinese children cancer group relapsed acute lymphoblastic leukemia 2017 Study (CCCG relapsed ALL 2017). Project 3: A New Clinical trial protocol for children with acute promyelocytic leukemia (APL) in Hong Kong.

This grant supports a Pediatric Neuro-Oncology Program Clinical Research Associate to ensure that more brain tumor patients can be treated on clinical trials, often their best hope for a cure.

This grant supports a Clinical Research Nurse to ensure that more kids can be treated on clinical trials, often their best hope for a cure. In the past, children diagnosed with cancer in the Rio Grande Valley had to travel to cities such as Houston or San Antonio to get state-or-the-art treatment through clinical trials. Physicians at the Vannie Cook Clinic in the Rio Grande Valley now have access to the most advanced trials and latest medications through Children's Oncology Group and other Texas-based clinical trials. This gives patients the opportunity to have the optimal outcome from their cancer therapy. More importantly, parents know that their child is getting the best care available, anywhere. That gives families hope that their child will live a long, healthy life.