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Dr. Ruff and colleagues will develop a targeted medical therapy for adamantinomatous craniopharyngioma, a brain tumor that affects children and causes lifelong vision loss, hormone problems, and cognitive impairment in the majority of survivors. Currently, the only treatments are surgery and radiation, which often cause irreversible damage to the developing brain, and despite this the tumor frequently comes back requiring repeated interventions. Combining two existing FDA-approved medications to shrink these tumors dramatically, Dr. Ruff and colleagues will study how likely these medications are to work in patients with this tumor. By analyzing tumor samples for the medication target and patient responses, Dr. Ruff and team will design a clinical trial that could transform care for children with this disease.