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In some children with cancer, their bodies become severely inflamed and they develop a condition known as hemophagocytic lymphohistiocytosis, or HLH, which is often deadly. It is not yet understood why some children with cancer develop HLH and others do not. Dr. Meyer is using advanced technologies to carefully study blood cells from children with cancer who develop HLH. She is also working to create the first model of this disease so that she can better study the underlying disease mechanisms. By increasing our understanding of HLH, she seeks to develop strategies that will help doctors quickly identify affected children and determine which medicines are most effective. Her overall goal is to help more children survive this devastating condition. If successful, her findings will apply not only to HLH, but also to other life-threatening immune system disorders resulting from cancer and/or its treatment.

This grant is funded by Allied World, a global provider of insurance and reinsurance solutions.