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Many children with bone tumors cannot be cured. This is true in particular if the tumor has come back. Dr. Gottschalk and colleagues will use the immune system to fight cancer. In their approach, they will take immune cells from patients and train them in the laboratory to fight cancer. Dr. Gottschalk and team's training methods willl consist of inserting a gene into immune cells that are a called T-cells. Once the cells have completed training in the laboratory, they are given back to patients. A second gene is inserted into T cells so that the T cells can grow better in patients after infusion. Dr. Gottschalk and colleagues will figure out the best structure of the second gene and will perform laboratory studies to determine which T cell works best, resulting in selecting the best T cell product for a future clinical study for children with bone tumors.