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Based on progress to date, Dr. John was awarded a new grant in 2018 to fund an additional year of this Fellow award. Unfortunately, even with intensive treatment, only 60% of children with acute myeloid leukemia (AML) will survive the disease. Intensifying standard therapies have failed to improve survival rates, so a new approach is needed. Dr. John is creating a novel receptor that will specifically target a marker on AML cells. He will put this new receptor on T-cells of the body, which will then target and kill the leukemia cells. Dr. John hopes to improve outcomes for pediatric AML with this grant.

This grant is generously supported by Super Soph's Pediatric Cancer Research Fund. Sophie Rossi was diagnosed with AML at 3 months of age. Throughout her courageous battle, she was always smiling, always joyful. This fund was created to honor her spunky, sweet spirit by funding research to find cures for AML and all childhood cancers.