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Based on progress to date, Dr. Crompton was awarded new grants in 2016 and 2017 to fund additional years of this Scholar award. Ewing sarcoma is an aggressive bone tumor affecting adolescents and young adults. Current treatment regimens fail to improve outcomes for patients with high-risk disease, and new therapeutic approaches are needed. Dr. Crompton's team recently identified a protein that is highly active in Ewing sarcoma and is targeted by drugs in clinical development. Dr. Crompton, the Team Clarkie Fund St. Baldrick’s Scholar, aims to demonstrate that these inhibitors warrant testing in clinical trials for patients with Ewing sarcoma, define the clinical indications for their use, and identify the most effective treatment combinations. Lastly, the project will develop a new screening effort to identify additional drug targets in Ewing sarcoma.

A portion of this grant is named for the Team Clarkie Fund created to honor Clarkie Carroll and fund Ewing’s sarcoma research while stimulating greater awareness and inspiring others to believe pediatric cancer research can and will lead to a cure.