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Based on progress to date, Dr. Barth was awarded new grants in 2016 and 2017 to fund additional years of this Scholar award. Children with B-cell non-Hodgkins lymphoma (B-NHL) whose disease is resistant to initial therapies have a dismal outcome. As the Do It For Dominic St. Baldrick's Scholar, Dr. Barth and his team have identified alterations in lymphoma cells that contribute to therapy resistance. This study investigates the ability to reverse or overcome resistance by targeting these altered pathways using targeted inhibitors. By inhibiting these pathways, he hopes to kill resistant lymphoma cells or re-sensitize resistant cells to traditional chemotherapy, potentially providing new future treatment options for patients with an otherwise poor prognosis.

This grant is named for the Do It for Dominic Fund which honors the memory of Dominic Cairo who battled non-Hodgkins lymphoma and was a hero to his school and community. His family and friends continue to raise funds and support research in the hopes that no child has to go through what Dominic endured.