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Diffuse midline glioma (DMG), previously known as diffuse intrinsic pontine glioma (DIPG), is a deadly childhood tumor with no effective treatments. Dr. Li's project seeks to understand the genetic and epigenetic dysregulation of DMGs. Through cutting-edge single-cell analyses and advanced AI models, researchers aim to map the tumor's epigenetic landscape, identify key regulatory elements, and predict the function of risk mutations. This knowledge could pave the way for new targeted therapies and improve DMG outcomes.

The final year of this three-year St. Baldrick's Scholar grant is funded by and named in honor of the Hannah Levy Miller Fund. Hannah passed away from Diffuse Intrinsic Pontine Glioma (DIPG) shortly before her 12th birthday. She was an avid reader who loved dancing, playing the cello, and playing soccer. To honor her memory and create a lasting legacy, her family established the Hero Fund to support research for DIPG. This mission reflects exactly what Hannah would have wanted—to help other children and families facing this devastating disease.

The first year St. Baldrick's Scholar award is funded by and named for #Joe Strong 71, a St. Baldrick’s Hero Fund created in memory of Joe Purdue. Joe was a talented football player and cherished friend and son. He was diagnosed with DIPG shortly after graduating from high school, cutting short his plans to attend college. He is remembered for determination as he battled the most lethal form of brain cancer. #Joe Strong 71 carries on Joe's legacy by funding research for DIPG.