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Tianzhong Yang Ph.D.
Funded: 07-01-2022
through 06-30-2026
Funding Type: St. Baldrick's Scholar
Institution Location:
Minneapolis, MN
Institution: University of Minnesota - Twin Cities
affiliated with Masonic Children's Hospital
Based on progress to date, Dr. Yang was awarded a new grant in 2024 and 2025 to fund an additional year of this Scholar grant. Hepatoblastoma is a very rare liver tumor diagnosed mainly among children younger than five years of age. Since it is hard to collect enough cases to study, researchers have not fully evaluated germline risk factor, i.e., the genetic information inherited from parents. Dr. Yang and colleagues have generated the largest germline genetic dataset for hepatoblastoma in the world, with which they can study the genetic causes of both onset and survival. They aim to better understand these genetic mechanisms to facilitate early detection and possibly identify targets of therapy for hepatoblastoma.
This grant is named for Julia's Legacy of Hope, a Hero Fund that honors Julia's positive, courageous spirit and carries out her last wish: "no child should have to go through what I have experienced". Diagnosed at 16 with Ewing sarcoma, Julia fought cancer and survived only to be stricken by a secondary cancer as a result of treatment. Her family is raising awareness and funds for research for Ewing sarcoma, as well as issues impacting Adolescent and Young Adult (AYA) patients.