Grants Search Results

Based on progress to date, Dr. Pinkney was awarded a new grant in 2014 to fund an optional third year of this fellowship. Kerice Pinkney, M.B.B.S., Gen Re St. Baldrick's Fellow, studies ATM, a protein that regulates the response of a cell when DNA is damaged. Mutation of ATM leads to increased breaks in DNA. This can then lead to chromosomal translocation, a process by which pieces of chromosomes are swapped. This can cause normal genes to combine together and lead to a new gene that can induce cancer. The goal of this project is to study how the protein ATM suppresses the translocation of chromosomes and therefore better understand the cause of pediatric cancers.

This grant is named for the General Reinsurance (Gen Re) team, which has raised more than $1 million to date for lifesaving research through the St. Baldrick's Foundation. Awarded at Columbia University and transferred to Joe DiMaggio Children's Hospital.

T-cell acute lymphoblastic leukemia (T-ALL) makes up 15% of childhood leukemia. There is a protein inside the cancer cells of patients with T-ALL that helps the cancer cells grow. Dr. Richard aims to decrease the amount of this protein so it cannot stimulate the cancer cells to grow. This will help to develop better treatments for children with T-cell leukemia.

The concept of resilience implies an ability to withstand stress after a significant crisis. While there are several theories of resilience, there is little consensus about how to define it or, more importantly, how to promote it. Cancer in children and adolescents can pose daunting challenges for patients as well as their families. This study explores a novel model of resilience among adolescents and parents of children with cancer. Promoting resilience during and after childhood cancer will promote more positive psychosocial outcomes and ultimately enable better family-level survivorship.

Based on progress to date, Dr. Schultz was awarded a new grant in 2014 to fund an optional third year of this fellowship. Acute myeloid leukemia (AML), a subtype of pediatric leukemia, has poor long-term outcomes, making it important to develop new treatments. Markit St. Baldrick's Fellow Dr. Liora Schultz's research focuses on taking advantage of the immune system to fight cancer. Cancer cells often go unrecognized by the immune system, and Dr. Schultz aims to genetically engineer immune cells to recognize and destroy cancer cells, and ultimately translate this technique to the clinic to treat pediatric patients with AML. Awarded at Memorial Sloan-Kettering Cancer Center and transferred to Stanford University.

This grant is named for Markit, Ltd., whose 24-hour head-shaving events worldwide have raised over $1 million to fund life-saving research through the St. Baldrick’s Foundation.

Based on progress to date, Dr. Davis was awarded a new grant in 2014 to fund an optional third year of this fellowship. Spread of tumor cells from their original site to distant areas (metastasis) is the most deadly aspect of cancer, and often occurs through lymphatic vessels. New vessels can grow around tumors to facilitate spread. To prevent this, we must understand why new vessels form, and the design that allows tumor cells to travel. Dr. Davis is studying etsrp, a protein believed to control lymphatic growth, which is therefore a novel therapeutic target for preventing metastasis in childhood cancer.

Based on progress to date, Dr. Wu was awarded a new grant in 2014 to fund an optional third year of this fellowship. Dr. Wu studies a kind of blood cancer called ALL (acute lymphoblastic leukemia), one of the most common types of childhood cancer. One of the main treatments for ALL is steroid therapy - not the steroids you take for bodybuilding, but the steroids you take if your asthma or your "bad back" is getting worse. This research is to understand why steroid treatment sometimes does not work in ALL. The main goal is to improve steroid treatment, to cure more patients.

This additional grant is named for Tap Cancer Out and recognizes the partnership with the jiu-jitsu based 501(c)(3) nonprofit who raises awareness and funds for cancer fighting organizations on behalf of the grappling community.

The original grant was named for Dr. Jeffrey Lipton in recognition of his tenure on the Board of Directors and in honor of his leadership, support and advocacy for childhood cancer research.

Based on progress to date, Dr. Barrett, was awarded a new grant in 2016 to fund an additional year of this Scholar award. While doctors can cure many children with leukemia, a significant number will have cancer that doesn't respond to chemotherapy or comes back (relapses). Dr. Barrett is working on a strategy to take a part of a patient's own immune system, the T cells, and redirect them towards the leukemia with an artificial construct called a chimeric antigen receptor (CAR). Early results indicate this approach works well, but more research about the T cells is necessary to fully harness their power. This therapy has the potential to save the lives of children with leukemia when chemotherapy and stem cell transplant cannot.

Based on progress to date, Dr. Chen, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Dr. Chen's research aims to discover new drugs that would prevent cancer relapse in children with rhabdomyosarcoma, one of the most common childhood cancers. She is testing drugs to see how effective they can be at killing rhabdomyosarcoma tumor cells and keeping kids with rhabdomyosarcoma cancer-free. Awarded at Brigham and Women's Hospital, Inc. and transferred to the University of Washington.

Based on progress to date, Dr. Davis, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Acute lymphoblastic leukemia (ALL) is a blood cancer and the most common cancer in children. Although great improvements have been made in curing this cancer, there are still children who die of ALL. Kara Davis, D.O., NetApp St. Baldrick's Scholar, focuses on how these cancer cells are related to normal developing blood cells, and how the ways these cells "communicate" are different from normal cell communication. This project also investigates how the communication in cancer cells is different in children who are are cured of their leukemia from those whose disease comes back.

This grant is named for the NetApp team, whose employees around the world have raised more than $3 million for research through the St. Baldrick's Foundation.

Based on progress to date, Dr. Friedman, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Medulloblastoma, the most common malignant pediatric brain tumor, is a leading cause of cancer-related death. Current treatments are harmful to the developing brain. Brain tumor-initiating cells (BTIC), which give rise to all tumor cells like a queen bee, are likely responsible for cancer recurrence. Genetically-altered herpes simplex virus, which has been used safely and effectively in adult trials, targets and kills tumor cells and BTIC while sparing normal brain cells. This laboratory is studying the use of clinically-ready viruses in difficult-to-treat medulloblastomas, to provide the foundation for future pediatric trials using this cutting-edge therapy to benefit children with these deadly cancers.

A portion of the grant was generously supported by the Miracles in Memory of Michael Fund, a St. Baldrick's Hero Fund created in memory of Michael Orbany and honors his tremendous strength to never ever give up.

This research seeks to improve treatment for AML, a childhood leukemia, by studying abnormalities in the leukemia-associated WT1 molecule. Studying changes in WT1 will help researchers better understand what causes leukemia, and how best to treat it. Most AML cancer cells have abnormally high WT levels compared to normal cells. This project studies ways to measure WT1 levels in blood samples after patients have received chemotherapy, in hopes of using WT1 as a marker of low-level disease, which may be difficult to detect, and as a target for treatments, which will directly affect these residual leukemia cells.

Based on progress to date, Dr. Lee, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Immune cells can now be engineered to recognize and kill cancer cells, then administered to patients. Dr. Lee's project is one of the first to bring this promising new therapy to children with cancer. This research aims to discover how these cells work, how to better harness their potential and to determine which cell types are important for effective and persistent anti-tumor activity. Several clinical trials of this breakthrough therapy for children with cancer are scheduled to open at this institution and others in the next few years, and this work will increase the chance that these trials will be effective against childhood cancer. Awarded at the National Cancer Institute, National Institutes of Health and transferred to University of Virginia.

A portion of the grant was generously supported by the Hope from Harper Hero Fund created to honor Harper Wehneman who passed away from Wilms tumor when she was 9 years old. This fund continues her legacy of inspiring joy and bringing hope to kids fighting cancer by funding research in the area of stem cell transplant survival.

Based on progress to date, Dr. Nakamura, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Survivors of childhood cancers are susceptible to developing second malignant neoplasms, which are complications of cancer treatments. Dr. Nakamura's lab has developed new experimental models that closely replicate this clinical problem, which they are using to study the biologic basis for second malignant neoplasms. This research improves the understanding of the genetic and biochemical mechanisms causing second malignant neoplasms, which may lead to improved cancer prevention strategies for childhood cancer survivors and the general population.

A portion grant is generously supported by the Morgan and Friends Fund, a St. Baldrick's Hero Fund, created to honor Morgan Loudon. It celebrates her strength and determination as a cancer survivor while rallying family and friends to “battle on” in the search for cures and better treatments.

Based on progress to date, Dr. Wang, was awarded a new grant in 2016 to fund an additional year of this Scholar award. AML (acute myelogenous leukemia) is an often-fatal disease in children and adolescents. Part of the reason for limited success in curing AML is that current therapies don't attack the cancer stem cells that are responsible for maintaining the leukemia. Dr. Wang's research seeks to identify specific ways to target those hard-to-kill AML stem cells. To do this Dr. Wang is using the cutting-edge technologies of phosphoproteomics, which allow researchers to look at biologically vital pathways in cancer stem cells in a comprehensive, efficient, and novel manner. Awarded at Children's Hospital Boston and transferred to City of Hope.

A portion of this research was funded by P.A.L.S. Bermuda with funds raised through the St. Baldrick's Foundation.

Based on progress to date, Dr. Parekh, was awarded a new grant in 2016 to fund an additional year of this Scholar award. T cell acute lymphoblastic leukemia (T-ALL) is a blood cancer that represents 15% of childhood leukemias. Of children with T-ALL, 20% fail to respond to therapy, and the survival for these children is less than 30%. Studying the mechanisms underlying the development of leukemia is critical for designing new treatments for T-ALL. Defects in the BCL11B gene are seen in T-ALL, and this project studies the role of BCL11B in the development of T-ALL, with the ultimate goal of understanding how T-ALL develops and identifying potential treatment strategies. Awarded at University of California, Los Angeles and transferred to Children's Hospital Los Angeles.

Based on progress to date, Dr. Pinto, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Prior to his 2015 relocation to Seattle, Dr. Pinto was the FOX Schools Challenge St. Baldrick's Scholar. He studies neuroblastoma, a childhood cancer of the nervous system. Factors such as patient age, extent of tumor spread, and tumor genetics are used to identify patients at highest risk of relapse, and these patients receive the most aggressive treatment. Despite this, more than half of these high-risk patients will die of disease. This project is using patient genetics to identify children that may be resistant to chemotherapy, allowing researchers to further refine the risk stratification and alter therapy for those patients at highest risk of relapse, to ultimately cure more children of this devastating disease. Awarded at the University of Chicago and transferred to Seattle Children's Hospital.

A portion of this grant was named for the FOX Schools Challenge, created in 2007 when Chicago area schools and students began to rally around the mission to Conquer Childhood Cancers, inspiring more than 15,000 people to shave and raising more than $5 million for childhood cancer research through the St. Baldrick's Foundation.

Filemon Dela Cruz, M.D., NetApp St. Baldrick's Scholar, studies ewing sarcoma, a common cancer of the bone and tissues in children. Despite our best therapies, less than 20% of children with widespread disease will survive. Dr. Dela Cruz's lab recently developed a model of Ewing sarcoma that has been genetically altered to mimic the early stages of this disease. This project aims to use this model to identify the biologic steps that went wrong in a cell to create Ewing's sarcoma, so that researchers can devise ways to correct and prevent these mistakes from ever occurring.

This grant is named for the NetApp team, whose employees around the world have raised more than $3 million for lifesaving research through the St. Baldrick's Foundation.

Based on progress to date, Dr. Mulcahy Levy, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Jean Mulcahy Levy, M.D., elope, Inc. St. Baldrick's Scholar Award, studies autophagy, a multi-step process that cancer can use to survive. It is possible to block this survival mechanism and hopefully make cancer easier to kill with other treatments like radiation and chemotherapy. This project has three goals to improve survival of children with brain tumors. First, to find which step of the process should be blocked to kill the most tumor cells. Second, to find which brain tumors depend most on autophagy to survive. And finally, to determine if a specific genetic mutation found in some pediatric brain tumors can identify patients who will most benefit from autophagy directed treatments.

This grant is named for elope, Inc., for its generous and faithful support of St. Baldrick's. The company has donated its popular green leprechaun hats and other whimsical attire to St. Baldrick's fundraising events, and the company's event has raised more than $1 million to fund lifesaving research.

Based on progress to date, Dr. Curran, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Our body can fight off infections using the immune system. This is why we feel better a few days after catching a cold. Our body can fight cancer in the same way, and the goal of Kevin Curran, M.D., AVM Traders St. Baldrick's Scholar's research is to teach the body to do that. This project aims to modify the immune system through gene therapy to create "cancer assassins" that target cancer cells. Ultimately, this method of cancer treatment may eliminate cancer without the side effects of current treatments such as chemotherapy (drugs) or radiation (x-rays).

This grant is named for AVM Traders, a company that has raised more than $1 million for childhood cancer research through the St. Baldrick's Foundation.

Ewing sarcoma relies on a gene called EWS-FLI1 to grow and spread throughout the body. Studies have previously shown a drug called ET-743 turns this gene off. In this work, Dr. Grohar's lab is trying to find drugs similar to ET-743 that may turn off EWS-FLI1 more effectively. In addition, they are looking to see if shutting down this gene creates a sensitivity to other chemotherapeutic drugs, especially the combination of ET-743 and a drug called irinotecan, which may be particularly effective at treating Ewing sarcoma.