Grants Search Results

Although most children with leukemia can be cured, chemotherapy frequently causes permanent brain dysfunction in survivors. With previous support from St. Baldricks, Dr. Cole's lab identified promising protective interventions, and he will now test them among those children at greatest risk for brain damage. To identify this population researchers are studying whether variation in neurocognitive function among leukemia survivors is related to specific inherited differences in genes related to repair mechanisms or to metabolism of drugs thought to cause cognitive deficits.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

One of 5 children with acute lymphoblastic leukemia suffers a relapse within 5 years of diagnosis. Also, Hispanic and African American children are more likely to relapse. Research has shown that 44% of the children are non-adherent to oral chemotherapy and that non-adherence is associated with an increased risk of relapse. This consortium has created a comprehensive package of interventions to improve adherence to oral chemotherapy. It is believed that this improvement in adherence will directly translate into an improvement in survival and a higher number of children cured of their cancer. Awarded at the Beckman Research Institute of the City of Hope and transferred to the University of Alabama at Birmingham. Funds administered by the University of Alabama at Birmingham.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This institution is a member of a research consortium which is being funded by St. Baldrick's: Comprehensive Approach to Improve Medication Adherence in Pediatric ALL. For a description of this project, see the consortium grant made to the lead institution: the University of Alabama at Birmingham, Birmingham, AL.

This grant funds a Clinical Research Coordinator and Clinical Research Associate to ensure that more kids can be treated on clinical trials, their best hope for a cure, at this institution.

This grant helped provide necessary resources to ensure that more kids can be treated on clinical trials, their best hope for a cure, at this institution.

This grant helps provide staffing to ensure that more kids can be treated on clinical trials, their best hope for a cure, at this institution.

This grant helps provide necessary resources at this institution to ensure that more kids can be treated on clinical trials, their best hope for a cure.

This grant helps provide necessary resources for the Late Effects/Survivorship Program at this institution to ensure that more kids can be treated on clinical trials, their best hope for a cure.

This grant brings together SIOP's Working Group on Essential Medicines, a group of experts from around the globe, to develop a multi-faceted approach to increase the availability of essential medicines for young people with childhood cancer world-wide.

There are currently over 350,000 childhood cancer survivors in the U.S., but treatments often result in persistent late-occurring health problems. One of the most devastating is congestive heart failure (CHF) resulting from treatment with a class of chemotherapy drugs called anthracyclines. It is estimated that 1 in 10 children treated with high-dose anthracyclines will develop CHF, with 1 in 2 dying within five years of diagnosis of CHF. Studies indicate that a low-dose blood pressure medication called carvedilol may help prevent the onset of CHF. This Consortium for Pediatric Intervention Research conducts a clinical trial with collaboration between five COG-member institutions. The project has the potential to not only improve overall cardiac function, but prevent the likelihood of developing CHF in survivors at highest risk. Funds administered by Beckman Research Institute of the City of Hope. Year two of this grant was generously funded by the Rally Foundation.

While currently 70% of children with brain tumors survive beyond 5-years from diagnosis, radiation to the brain and spine are cornerstones of therapy. The cost of this treatment is impaired neuro-cognitive function, premature heart problems, stroke, and impaired quality of life in many. The role of injury to the heart and vascular system from radiation has not been previously studied in childhood brain tumor survivors. While killing tumor cells, radiation may lead to narrowing and stiffening of the vessels in the brain. Stiffening of the aorta is a progressive with normal aging in the lifespan. This project studies stiffness in the aorta and its relation to flow in the vessels in the brain among children who received radiation therapy, a novel attempt to link the heart and the brain following childhood cancer. 

The treatments used to cure pediatric cancers can cause infertility. Banking sperm at diagnosis is the gold standard for preserving fertility for boys who have reached puberty, but is not an option for younger boys who do not yet have mature sperm in their testicles. The prepubertal testicle does contain a small number of stem (parent) cells that will eventually become mature sperm, so one new idea is the use of testicular tissue frozen at diagnosis, then later thawed with the parent cells reimplanted into the testis to mature or matured outside the body and then used with assistive reproductive techniques. This consortium is collecting testicular tissue samples to increase the amount of tissue available for research, in the hope of providing an option for fertility preservation to patients who currently have no options at all.  Funds administered by the Children's Hospital of Philadelphia.

Adolescents with cancer experience many symptoms resulting from their disease and its treatment. Recognizing and managing these contributes to improved quality of life during treatment and on into survivorship. This study uses an approach that allows adolescents to identify clusters describing their symptom experience from their perspective. The purpose is to develop and test the use of a computer-based tool exploring symptom clusters among adolescents with cancer. The goal of these findings is to provide data to support use of the tool in a larger group of adolescents and to enhance communication between them and healthcare providers.

This institution is a member of a research consortium which is being funded by St. Baldrick's: the Consortium for Pediatric Intervention Research. For a description of this project, "Pharmacologic prevention of heart failure in survivors of childhood cancer," see the consortium grant made to the lead institution: the Beckman Research Institute of the City of Hope, Duarte, CA. Year two of this grant was generously funded by the Rally Foundation.

This institution is a member of a research consortium which is being funded by St. Baldrick's: the Consortium for Pediatric Intervention Research. For a description of this project, "Pharmacologic prevention of heart failure in survivors of childhood cancer," see the consortium grant made to the lead institution: the Beckman Research Institute of the City of Hope, Duarte, CA. Year two of this grant was generously funded by the Rally Foundation.

This institution is a member of a research consortium which is being funded by St. Baldrick's: the Consortium for Pediatric Intervention Research. For a description of this project, "Pharmacologic prevention of heart failure in survivors of childhood cancer," see the consortium grant made to the lead institution: the Beckman Research Institute of the City of Hope, Duarte, CA. Year two of this grant was generously funded by the Rally Foundation.