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Dr. Schultz and team will examine what happens to children after CAR T therapy for leukemia, an immunotherapy that can put cancer into remission when standard treatments, such as chemotherapy, have failed. While many children now survive, doctors do not fully understand the long-term effects. Dr. Schultz's team will study 700 children who have received this therapy and will collect surveys from a subset of patients and caregivers about quality of life and real-world challenges. By combining medical data with patient experiences, this study will uniquely identify which children are most at risk for long term problems and why. This work will help doctors better predict these risks and guide follow-up care so children not only survive leukemia, but achieve prolonged years of highest quality and function after treatment.