Based on progress to date, Dr. Boston was awarded a new grant in 2015 to fund an optional third year of this fellowship. Studies show that a robust immune system improves survival of patients with cancer, which may explain why patients with the same cancer treatment have different outcomes. This project aims to find a treatment which can enhance the patient's immune system, potentially improving outcomes, by measuring immune system responses to chemotherapy, testing immune-enhancing drugs, and performing a clinical trial to determine whether these drugs are effective in enhancing the immune system in children with cancer. Awarded at UT M.D. Anderson and transferred to Our Lady of the Lake, St. Jude Children's Research Hospital Baton Rouge Affiliate.