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Case Western Reserve University Summer Fellow
Funded: 05-26-2020
through 01-31-2021
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Cleveland, OH
Institution: Case Western Reserve University
This grant funds a student to complete work in pediatric oncology research for the summer. Osteosarcoma (OS) is the most common and highly lethal bone cancer affecting children and adolescent populations. New therapies are desperately needed for this highly aggressive disease, as outcome for metastatic OS has not improved over the past few decades despite the utilization of aggressive combination chemotherapy. The summer fellow will focus on testing a novel CA-IX small molecule inhibitor using syngeneic OS tumors in vitro and in vivo. Activities generated through this Summer Fellowship grant will lay the foundation for pre-clinical data for the use of CA-IX inhibitor in future clinical trials.
University of California, San Francisco Summer Fellow
Funded: 05-18-2020
through 08-17-2020
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
San Francisco, CA
Institution: University of California, San Francisco
affiliated with UCSF Benioff Children's Hospital
This grant funds an undergraduate student and a medical student to complete work in pediatric oncology research for the summer. Neuroblastoma is a pediatric tumor in which a large subset has very poor survival. Researchers are trying to understand what makes this subset so deadly and have developed a system to test combinations of genes apart and together to determine how they could make certain neuroblastoma more aggressive. They will test whether certain mutations may make the neuroblastoma tumor cells more invasive and if these mutations could cause other critical gene expression changes in high risk neuroblastoma.
Creighton University Summer Fellow
Funded: 05-18-2020
through 02-28-2021
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Omaha, NE
Institution: Creighton University
This grant funds two undergraduate students to complete work in pediatric oncology research for the summer. Tumors have extensive mutations in their DNA which play important roles in cancer development. Particular mutations that are frequently found in tumors are likely important for promoting cancer development. BubR1 is a protein that regulates the proper separation of DNA during cell division, and therefore plays an important role in suppressing cancer formation. A mutation in BubR1 (R249Q) is specifically observed in approximately 15% of pediatric cancers and is not found in adult cancers. Researchers will study this mutation and results may identify a unique mechanism of tumor development controlled by BubR1 specifically during developmental processes, uniquely promoting pediatric cancer. This project will provide an opportunity for these two students to spend the summer performing biomedical science research utilizing well-established and easy to learn techniques, to enhance their excitement in pediatric cancer research.
Georgetown University Summer Fellow
Funded: 05-15-2020
through 10-30-2021
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Washington, DC
Institution: Georgetown University
affiliated with MedStar Georgetown University Hospital
This grant funds an undergraduate student to complete work in pediatric oncology research for the summer. Ewing sarcoma is a cancer that primarily occurs in children, adolescents, and young adults. While we don't know why certain people get Ewing sarcoma, we do know that most patients have the same problem with genes in their cancer cell. Just as genes affect your eye color, the Ewing sarcoma cells have a special gene, EWS-FLI1, that keeps the cancer growing. EWS-FLI1 is critical for Ewing sarcoma cells to survive. If you turn off EWS-FLI1, Ewing sarcoma cells die. This project will study exactly how YK-4-279, a chemical in a new drug in clinical trials, affects key survival processes, called transcription and splicing, to enable design of optimized drugs. This grant is named for the St. Baldrick's Foundation Staff whose generous gifts have helped fund this opportunity and may encourage students to choose childhood cancer research as a specialty.
Virginia Polytechnic Institute and State University Summer Fellow
Funded: 05-15-2020
through 02-15-2021
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Blacksburg, VA
Institution: Virginia Polytechnic Institute and State University
This grant funds a medical student to complete work in pediatric oncology research for the summer. Pediatric glioblastoma (p-GBM) is a lethal brain tumor that can affect children. This cancer is difficult to treat due to several factors, including the tumor's resistance to conventional therapies as well as the sensitivity of the surrounding healthy brain tissue. Children who undergo surgery to remove the brain tumor live an additional three to six years on average, though the quality of life may be low. Phosphoinositide 3-kinase (PI3K) is a protein family that normally regulates cell replication and survival. However, when it functions incorrectly, cells can experience unchecked growth and cause cancer. Inhibiting this protein family is a viable treatment option for cancer but blocking the whole PI3K family has severe side effects. It is imperative to understand each member of the PI3K family to better develop treatments that involve them.
University of Vermont and State Agricultural College Summer Fellow
Funded: 05-01-2020
through 04-30-2021
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Burlington, VT
Institution: University of Vermont and State Agricultural College
affiliated with Vermont Children’s Hospital at the UVM Medical Center
This grant funds an undergraduate student to complete work in pediatric oncology research for the summer. Diffuse intrinsic pontine glioma (DIPG) is a type of children's brain tumor that currently has no cure or effective therapeutic options. This proposal aims to understand whether the target drug of ONC201, ClpP, can be targeted using novel compounds representing new potential therapeutics in DIPG.
New York University Summer Fellow
Funded: 05-01-2020
through 04-30-2021
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
New York, NY
Institution: New York University School of Medicine
affiliated with NYU Langone Medical Center
This grant funds an undergraduate student to complete work in pediatric oncology research for the summer. DIPG's are the worst type of brain cancer children can get; there is no cure. This project will try a new approach to change that. Using large publicly available datasets from large experiments, 4 drugs have been identified that theoretically can slow down the growth of DIPG tumors. Researchers will test these four drugs against several DIPG models generated from patients. If results are positive, this could lead to new treatments for this deadly disease.
The University of Tennessee Summer Fellow
Funded: 05-01-2020
through 09-30-2020
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Memphis, TN
Institution: University of Tennessee Health Science Center
This grant funds a medical student to complete work in pediatric oncology research for the summer. This year it is estimated that 800 children will be diagnosed with osteosarcoma (bone cancer). The lab has identified a gene (WNT5B) that is too high in a subset of osteosarcomas. By making a cell line that removes WNT5B, the lab will compare its growth to the original cells and target this gene in those cancers that have it to design a specific targeted therapy.
Children's Hospital, Los Angeles Summer Fellow
Funded: 05-01-2020
through 10-31-2020
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Los Angeles, CA
Institution: Children's Hospital Los Angeles
This grant funds two students to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty. Project 1: Neuroblastomas are an enigmatic cancer of childhood with subtypes that have extremely good or poor survival. Poor prognosis neuroblastomas contain normal immune cells that help tumors grow. Important questions are 1) what is the repertoire of immune cells in neuroblastomas at time of diagnosis, 2) how the interplay between normal and tumor cells changes when tumors recur. The Summer Fellow will analyze images of tumors at recurrence and compare to the diagnosis images. These findings will provide insights into the types of immune cells that cancer cells rely on and may allow identification of new targets of therapy. Project 2: Decline in brain function may happen after irradiation to the brain in children. It is hard to predict the extent and speed by which it happens. There is suggestion that more rapid injury happens in areas with iron deposition. Using a novel MRI method that allows chemical identification and quantification of iron in the brain, the Summer Fellow will characterize the imaging changes in white matter of the brain in children who have been treated with radiation for their brain tumors. This will allow to then correlate the changes with future outcome of their cognitive function.
University of Wisconsin-Madison Summer Fellow
Funded: 05-01-2020
through 12-31-2020
Funding Type: St. Baldrick's Summer Fellow
Institution Location:
Madison, WI
Institution: University of Wisconsin-Madison
affiliated with American Family Children's Hospital
This grant funds an undergraduate student to complete work in pediatric oncology research for the summer. High risk neuroblastoma remains a challenge to cure with only 50% survival, despite multi-modality treatment. Natural killer (NK) cells have been previously shown to have activity versus neuroblastoma but have not been consistently successful in clinical trials. In similar fashion to how people receive flu shots, this project will treat bone marrow transplant recipients with 3 doses of a vaccine, with or without anti-PD1 therapy to stimulate T and NK cells, to introduce their immune system to what neuroblastoma looks like, so in the event this tumor tries to grow, the immune system will stop it and kill it before making the patient sick. This grant is named for the St. Baldrick's Foundation Staff whose generous gifts have helped fund this opportunity and may encourage students to choose childhood cancer research as a specialty.
Poul Sorensen M.D.
Funded: 01-01-2020
through 12-31-2023
Funding Type: Research Grant
Institution Location:
Vancouver, BC
Institution: The University of British Columbia
affiliated with British Columbia Children's Hospital, British Columbia Cancer Agency
Ewing Sarcoma (EwS) is an aggressive bone and soft tissue tumor occurring in children and young adults. Approximately 25-30% of patients already have metastases at diagnosis and in spite of aggressive treatment, the survival for patients with metastatic disease remains dismal. EwS is considered an immune cold tumor that is largely resistant to conventional immunotherapy. Alternative treatment approaches are sorely needed, particularly in patients with metastatic disease. Dr. Sorensen and colleagues are using three novel strategies for targeting EwS tumors: 1) Inhibiting an EwS specific fusion protein that drives EwS tumor development. 2) Targeting a surface protein called IL1RAP. 3) Recruiting natural killer (NK) immune cells to EwS tumors and priming them to attack the tumor. This grant is the result of a generous anonymous donation to fund Ewing sarcoma research, specifically. It is in honor of a teenager fighting Ewing sarcoma, and is named the St. Baldrick's - Martha's Better Ewing Sarcoma Treatment (BEST) Grant for All.
Catherine A Long M.D.
Funded: 01-01-2020
through 06-30-2021
Funding Type: Infrastructure Grant
Institution Location:
Green Bay, WI
Institution: St. Vincent Hospital Regional Cancer Center
This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.
Eric Lowe M.D.
Funded: 01-01-2020
through 12-31-2020
Funding Type: Infrastructure Grant
Institution Location:
Norfolk, VA
Institution: Children's Hospital of The King's Daughters
affiliated with Eastern Virginia Medical School
This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.
Ashraf Mohamed M.D.
Funded: 01-01-2020
through 12-31-2022
Funding Type: Infrastructure Grant
Institution Location:
Ft. Worth, TX
Institution: Cook Children's Medical Center
Integrative oncology is a patient-centered, evidence-informed field of cancer care that uses mind and body practices, natural products, and lifestyle modifications from various traditions alongside traditional cancer treatments. Many complementary and alternative medicine approaches have been shown to improve symptom control and quality of life for patients and survivors. The field of integrative oncology has emerged in recent years as interest in and the use of these therapies have grown. The goal of this scientific discipline is to combine evidence-based complementary medicine and traditional cancer treatment to address the diverse needs of patients with cancer and their families. This grant supports an Integrative and Supportive Care Oncology Coordinator to ensure that more kids can be treated on supportive care and integrative oncology clinical trials.
Shannon Cohn M.D.
Funded: 01-01-2020
through 12-31-2021
Funding Type: Infrastructure Grant
Institution Location:
Austin, TX
Institution: Dell Children's Medical Center of Central Texas
This grant supports a research coordinator to ensure that more kids can be treated on clinical trials, often their best hope for a cure.
Lisa Hartman M.D.
Funded: 01-01-2020
through 12-31-2020
Funding Type: Infrastructure Grant
Institution Location:
El Paso, TX
Institution: El Paso Children's Hospital
This grant supports a bilingual Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.
Rene McNall-Knapp M.D.
Funded: 01-01-2020
through 12-31-2020
Funding Type: Infrastructure Grant
Institution Location:
Oklahoma City, OK
Institution: University of Oklahoma Health Sciences Center
affiliated with The Children's Hospital at OU Medical Center
This grant supports a clinical research nurse to ensure that more kids can be treated on early phase clinical trials, often their best hope for a cure.
Katharine Offer M.D.
Funded: 01-01-2020
through 12-31-2020
Funding Type: Infrastructure Grant
Institution Location:
Hackensack, NJ
Institution: Hackensack University Medical Center
affiliated with Tomorrows Children's Institute
This grant supports a pediatric solid tumor program Clinical Research Associate to ensure that more solid tumor patients can be treated on clinical trials, often their best hope for a cure.
William S. Ferguson M.D.
Funded: 01-01-2020
through 12-31-2020
Funding Type: Infrastructure Grant
Institution Location:
St. Louis, MO
Institution: SSM Cardinal Glennon Children's Hospital
affiliated with Saint Louis University
This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.
Katharine Lange M.D.
Funded: 01-01-2020
through 06-30-2021
Funding Type: Infrastructure Grant
Institution Location:
Minneapolis, MN
Institution: Children's Hospitals and Clinics of Minnesota
affiliated with Children's - St. Paul
Over 80% of children treated for childhood cancers will become long term survivors. With this success in survival comes the challenge of caring for survivors and their unique long term follow up needs. As late effects of childhood cancer treatment are continuing to be described, it is essential that survivors are enrolled on clinical trials that monitor outcomes to inform late effects guidelines. In addition, more emphasis is being placed on intervention trials for survivors which are critically important in increasing survivors' access to state of the art interventions as well as increasing knowledge about how best to help the survivor population. This grant supports a dedicated Survivorship Clinical Research Associate to ensure that more survivors of childhood cancer can have access to clinical trials targeted at the survivorship population.