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Showing 1541-1560 of 2390 results
Amy Barone M.D.
Funded: 07-01-2012
through 06-30-2014
Funding Type: St. Baldrick's Fellow
Institution Location:
St. Louis, MO
Institution: Washington University in St. Louis
affiliated with St. Louis Children's Hospital
Despite decades of research, children with glioblastoma multiforme (a type of brain cancer) rarely survive more than three years. This project is testing a new drug (CC11050) that might treat this type of cancer, and may lead to clinical trials in children with glioblastoma multiforme to improve cure rates.
Catherine Boston M.D.
Funded: 07-01-2012
through 09-30-2017
Funding Type: St. Baldrick's Fellow
Institution Location:
Baton Rouge, LA
Institution: Our Lady of the Lake Regional Medical Center, St. Jude Children's Research Hospital Baton Rouge Affiliate
Based on progress to date, Dr. Boston was awarded a new grant in 2015 to fund an optional third year of this fellowship. Studies show that a robust immune system improves survival of patients with cancer, which may explain why patients with the same cancer treatment have different outcomes. This project aims to find a treatment which can enhance the patient's immune system, potentially improving outcomes, by measuring immune system responses to chemotherapy, testing immune-enhancing drugs, and performing a clinical trial to determine whether these drugs are effective in enhancing the immune system in children with cancer. Awarded at UT M.D. Anderson and transferred to Our Lady of the Lake, St. Jude Children's Research Hospital Baton Rouge Affiliate.
Erin Breese M.D., Ph.D.
Funded: 07-01-2012
through 07-31-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Palo Alto, CA
Institution: Stanford University
affiliated with Lucile Packard Children’s Hospital
Based on progress to date, Dr. Breese was awarded a new grant in 2014 to fund an optional third year of this fellowship. When a parent hears that their child has leukemia, one of the first questions doctors hear is, "Why?" Years of research on this question has shown that there are critical changes that happen in a cell that lead to the development of leukemia. Using new technology, this project is to recreate the genetic changes that play an important role in the development of many types of leukemia. This will help us to better understand why children develop cancer and to develop more focused therapies to improve our ability to cure childhood leukemias.
Michael Ferguson M.D.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Indianapolis, IN
Institution: Riley Hospital for Children
affiliated with Indiana University, IU Health Proton Therapy Center
Based on progress to date, Dr. Ferguson was awarded a new grant in 2014 to fund an optional third year of this fellowship. Neurofibromatosis type I is a rare genetic disorder that affects about 100,000 people in the United States alone. Of children with this disease, 25-40% form slow growing tumors called plexiform neurofibromas. These tumors can cause disfigurement, disability, and even death, depending on their location. To date, there is no effective therapy to treat these tumors. This project is testing drugs, already developed by pharmaceutical companies, that block growth in other cancers, for plexiform neurofibromas. The purpose of this study is to find a life-saving treatment for children with these tumors.
Chandrika Gowda M.D.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Hershey, PA
Institution: Pennsylvania State University
affiliated with Penn State Hershey Children's Hospital
Based on progress to date, Dr. Gowda was awarded a new grant in 2014 to fund an optional third year of this fellowship. This project studies the regulation of the function of the Ikaros protein. The loss of function of the Ikaros protein is associated with the development of acute lymphoblastic leukemia (ALL) that does not respond well to current therapies. Dr. Gowda is studying the way that Ikaros prevents the development of leukemia and to explain why the loss Ikaros activity leads to the development of leukemia. Thus, the results of this project will give insight into the mechanism of leukemia development. The more researchers learn about the way a cell changes to a cancer cell, the easier it will be to find new and more effective treatment options for patients with childhood leukemia.
Birgit Knoechel M.D., Ph.D.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Boston, MA
Institution: Dana-Farber Cancer Institute
affiliated with Boston Children's Hospital, Harvard Medical School
Based on progress to date, Dr. Knoechel was awarded a new grant in 2014 to fund an optional third year of this fellowship. Approximately 15% of children with leukemia have a form known as T-cell acute lymphoblastic leukemia (ALL). Current chemotherapy initially works very well in this type of ALL, however many of these patients have a recurrence early in their treatment. There are factors that are known to add to the development of a cancer and how well drugs work against it. These factors are known as chromatin regulators. Birgit Knoechel, M.D., Ph.D., Porter Dowling St. Baldrick's Fellow, is studying a chromatin regulator, BRD4, and how effective it is in reducing the drug resistance in T-cell ALL. These findings, along with a newly developed inhibitor that specifically targets BRD4, may provide a new approach to the treatment of T-cell ALL. This grant is named for Porter Dowling, in recognition for raising more than $1.2 million for childhood cancer research through the St. Baldrick's Foundation.
Emily Moses M.D.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Charlottesville, VA
Institution: University of Virginia Children's Hospital
Based on progress to date, Dr. Moses was awarded a new grant in 2014 to fund an optional third year of this fellowship. Salinomycin, an antibiotic used in agriculture, has recently been shown to be highly effective against cancer stem cells, which are the resistant cells that contribute to relapse. This project aims to determine whether this antibiotic, in combination with standard treatment, can be used to effectively treat childhood brain cancers that develop resistance to standard treatment. The knowledge generated from this study will provide a new concept for treatment of brain tumors to achieve tumor eradication and potentially cure. Awarded at the University of Texas HSC San Antonio and transferred to the University of Virginia.
This grant is made with generous support from the McKenna Claire Foundation established by the Wetzel family in memory of their daughter, McKenna. Their mission is to cure pediatric brain cancer by raising awareness, increasing community involvement and funding research.
Kerice Pinkney M.B.B.S.
Funded: 07-01-2012
through 09-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Hollywood, FL
Institution: Joe DiMaggio Children's Hospital
Based on progress to date, Dr. Pinkney was awarded a new grant in 2014 to fund an optional third year of this fellowship. Kerice Pinkney, M.B.B.S., Gen Re St. Baldrick's Fellow, studies ATM, a protein that regulates the response of a cell when DNA is damaged. Mutation of ATM leads to increased breaks in DNA. This can then lead to chromosomal translocation, a process by which pieces of chromosomes are swapped. This can cause normal genes to combine together and lead to a new gene that can induce cancer. The goal of this project is to study how the protein ATM suppresses the translocation of chromosomes and therefore better understand the cause of pediatric cancers.
This grant is named for the General Reinsurance (Gen Re) team, which has raised more than $1 million to date for lifesaving research through the St. Baldrick's Foundation. Awarded at Columbia University and transferred to Joe DiMaggio Children's Hospital.
Nameeta Richard M.D.
Funded: 07-01-2012
through 06-30-2013
Funding Type: St. Baldrick's Fellow
Institution Location:
Portland, OR
Institution: Oregon Health and Science University
affiliated with Doernbecher Children's Hospital
T-cell acute lymphoblastic leukemia (T-ALL) makes up 15% of childhood leukemia. There is a protein inside the cancer cells of patients with T-ALL that helps the cancer cells grow. Dr. Richard aims to decrease the amount of this protein so it cannot stimulate the cancer cells to grow. This will help to develop better treatments for children with T-cell leukemia.
Abby Rosenberg M.D.
Funded: 07-01-2012
through 06-30-2014
Funding Type: St. Baldrick's Fellow
Institution Location:
Seattle, WA
Institution: Seattle Children's Hospital
affiliated with Fred Hutchinson Cancer Research Center, University of Washington
The concept of resilience implies an ability to withstand stress after a significant crisis. While there are several theories of resilience, there is little consensus about how to define it or, more importantly, how to promote it. Cancer in children and adolescents can pose daunting challenges for patients as well as their families. This study explores a novel model of resilience among adolescents and parents of children with cancer. Promoting resilience during and after childhood cancer will promote more positive psychosocial outcomes and ultimately enable better family-level survivorship.
Liora Schultz M.D.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Palo Alto, CA
Institution: Stanford University
affiliated with Lucile Packard Children’s Hospital
Based on progress to date, Dr. Schultz was awarded a new grant in 2014 to fund an optional third year of this fellowship. Acute myeloid leukemia (AML), a subtype of pediatric leukemia, has poor long-term outcomes, making it important to develop new treatments. Markit St. Baldrick's Fellow Dr. Liora Schultz's research focuses on taking advantage of the immune system to fight cancer. Cancer cells often go unrecognized by the immune system, and Dr. Schultz aims to genetically engineer immune cells to recognize and destroy cancer cells, and ultimately translate this technique to the clinic to treat pediatric patients with AML. Awarded at Memorial Sloan-Kettering Cancer Center and transferred to Stanford University.
This grant is named for Markit, Ltd., whose 24-hour head-shaving events worldwide have raised over $1 million to fund life-saving research through the St. Baldrick’s Foundation.
Jennifer Davis D.O.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Cincinnati, OH
Institution: Cincinnati Children's Hospital Medical Center
affiliated with University of Cincinnati College of Medicine
Based on progress to date, Dr. Davis was awarded a new grant in 2014 to fund an optional third year of this fellowship. Spread of tumor cells from their original site to distant areas (metastasis) is the most deadly aspect of cancer, and often occurs through lymphatic vessels. New vessels can grow around tumors to facilitate spread. To prevent this, we must understand why new vessels form, and the design that allows tumor cells to travel. Dr. Davis is studying etsrp, a protein believed to control lymphatic growth, which is therefore a novel therapeutic target for preventing metastasis in childhood cancer.
Jennifer Wu M.D., Ph.D.
Funded: 07-01-2012
through 06-30-2015
Funding Type: St. Baldrick's Fellow
Institution Location:
Boston, MA
Institution: Boston Children's Hospital
affiliated with Dana-Farber Cancer Institute, Harvard Medical School
Based on progress to date, Dr. Wu was awarded a new grant in 2014 to fund an optional third year of this fellowship. Dr. Wu studies a kind of blood cancer called ALL (acute lymphoblastic leukemia), one of the most common types of childhood cancer. One of the main treatments for ALL is steroid therapy - not the steroids you take for bodybuilding, but the steroids you take if your asthma or your "bad back" is getting worse. This research is to understand why steroid treatment sometimes does not work in ALL. The main goal is to improve steroid treatment, to cure more patients.
This additional grant is named for Tap Cancer Out and recognizes the partnership with the jiu-jitsu based 501(c)(3) nonprofit who raises awareness and funds for cancer fighting organizations on behalf of the grappling community.
The original grant was named for Dr. Jeffrey Lipton in recognition of his tenure on the Board of Directors and in honor of his leadership, support and advocacy for childhood cancer research.
David Barrett M.D., Ph.D.
Funded: 07-01-2012
through 06-30-2017
Funding Type: St. Baldrick's Scholar
Institution Location:
Philadelphia, PA
Institution: The Children's Hospital of Philadelphia
affiliated with University of Pennsylvania
Based on progress to date, Dr. Barrett, was awarded a new grant in 2016 to fund an additional year of this Scholar award. While doctors can cure many children with leukemia, a significant number will have cancer that doesn't respond to chemotherapy or comes back (relapses). Dr. Barrett is working on a strategy to take a part of a patient's own immune system, the T cells, and redirect them towards the leukemia with an artificial construct called a chimeric antigen receptor (CAR). Early results indicate this approach works well, but more research about the T cells is necessary to fully harness their power. This therapy has the potential to save the lives of children with leukemia when chemotherapy and stem cell transplant cannot.
Eleanor Chen M.D., Ph.D.
Funded: 07-01-2012
through 06-30-2017
Funding Type: St. Baldrick's Scholar
Institution Location:
Seattle, WA
Institution: University of Washington
affiliated with Fred Hutchinson Cancer Research Center, Seattle Children's Hospital
Based on progress to date, Dr. Chen, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Dr. Chen's research aims to discover new drugs that would prevent cancer relapse in children with rhabdomyosarcoma, one of the most common childhood cancers. She is testing drugs to see how effective they can be at killing rhabdomyosarcoma tumor cells and keeping kids with rhabdomyosarcoma cancer-free. Awarded at Brigham and Women's Hospital, Inc. and transferred to the University of Washington.
Kara Davis D.O.
Funded: 07-01-2012
through 06-30-2017
Funding Type: St. Baldrick's Scholar
Institution Location:
Palo Alto, CA
Institution: Stanford University
affiliated with Lucile Packard Children’s Hospital
Based on progress to date, Dr. Davis, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Acute lymphoblastic leukemia (ALL) is a blood cancer and the most common cancer in children. Although great improvements have been made in curing this cancer, there are still children who die of ALL. Kara Davis, D.O., NetApp St. Baldrick's Scholar, focuses on how these cancer cells are related to normal developing blood cells, and how the ways these cells "communicate" are different from normal cell communication. This project also investigates how the communication in cancer cells is different in children who are are cured of their leukemia from those whose disease comes back.
This grant is named for the NetApp team, whose employees around the world have raised more than $3 million for research through the St. Baldrick's Foundation.
Gregory Friedman M.D.
Funded: 07-01-2012
through 06-30-2017
Funding Type: St. Baldrick's Scholar
Institution Location:
Birmingham, AL
Institution: University of Alabama at Birmingham
affiliated with Children's of Alabama
Based on progress to date, Dr. Friedman, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Medulloblastoma, the most common malignant pediatric brain tumor, is a leading cause of cancer-related death. Current treatments are harmful to the developing brain. Brain tumor-initiating cells (BTIC), which give rise to all tumor cells like a queen bee, are likely responsible for cancer recurrence. Genetically-altered herpes simplex virus, which has been used safely and effectively in adult trials, targets and kills tumor cells and BTIC while sparing normal brain cells. This laboratory is studying the use of clinically-ready viruses in difficult-to-treat medulloblastomas, to provide the foundation for future pediatric trials using this cutting-edge therapy to benefit children with these deadly cancers.
A portion of the grant was generously supported by the Miracles for Michael Fund, a St. Baldrick's Hero Fund created in memory of Michael Orbany and honors his tremendous strength to never ever give up.
Phoenix Ho M.D.
Funded: 07-01-2012
through 08-31-2014
Funding Type: St. Baldrick's Scholar
Institution Location:
Seattle, WA
Institution: Fred Hutchinson Cancer Research Center
affiliated with University of Washington, Seattle Children's Hospital
This research seeks to improve treatment for AML, a childhood leukemia, by studying abnormalities in the leukemia-associated WT1 molecule. Studying changes in WT1 will help researchers better understand what causes leukemia, and how best to treat it. Most AML cancer cells have abnormally high WT levels compared to normal cells. This project studies ways to measure WT1 levels in blood samples after patients have received chemotherapy, in hopes of using WT1 as a marker of low-level disease, which may be difficult to detect, and as a target for treatments, which will directly affect these residual leukemia cells.
Daniel Lee M.D.
Funded: 07-01-2012
through 06-30-2018
Funding Type: St. Baldrick's Scholar
Institution Location:
Charlottesville, VA
Institution: University of Virginia Children's Hospital
Based on progress to date, Dr. Lee, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Immune cells can now be engineered to recognize and kill cancer cells, then administered to patients. Dr. Lee's project is one of the first to bring this promising new therapy to children with cancer. This research aims to discover how these cells work, how to better harness their potential and to determine which cell types are important for effective and persistent anti-tumor activity. Several clinical trials of this breakthrough therapy for children with cancer are scheduled to open at this institution and others in the next few years, and this work will increase the chance that these trials will be effective against childhood cancer. Awarded at the National Cancer Institute, National Institutes of Health and transferred to University of Virginia.
A portion of the grant was generously supported by the Hope from Harper Hero Fund created to honor Harper Wehneman who passed away from Wilms tumor when she was 9 years old. This fund continues her legacy of inspiring joy and bringing hope to kids fighting cancer by funding research in the area of stem cell transplant survival.
Jean Nakamura M.D.
Funded: 07-01-2012
through 06-30-2017
Funding Type: St. Baldrick's Scholar
Institution Location:
San Francisco, CA
Institution: University of California, San Francisco
affiliated with UCSF Benioff Children's Hospital
Based on progress to date, Dr. Nakamura, was awarded a new grant in 2016 to fund an additional year of this Scholar award. Survivors of childhood cancers are susceptible to developing second malignant neoplasms, which are complications of cancer treatments. Dr. Nakamura's lab has developed new experimental models that closely replicate this clinical problem, which they are using to study the biologic basis for second malignant neoplasms. This research improves the understanding of the genetic and biochemical mechanisms causing second malignant neoplasms, which may lead to improved cancer prevention strategies for childhood cancer survivors and the general population.
A portion grant is generously supported by the Morgan and Friends Fund, a St. Baldrick's Hero Fund, created to honor Morgan Loudon. It celebrates her strength and determination as a cancer survivor while rallying family and friends to “battle on” in the search for cures and better treatments.