Research

Our St. Baldrick’s Foundation Research Outcomes blogs highlight examples of the progress your donations are supporting. This quarterly edition focuses on a new treatment target for neuroblastoma, improving CAR T-Cell effectiveness, using ultrasound to reach brain tumors, and preventing heart failure in childhood cancer survivors.

Thank you for making this research possible.

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Dr. Eric Raabe

Join us as we follow the journey of Dr. Eric Raabe’s research, funded by the St. Baldrick’s Foundation Hero Fund, Hannah’s Heroes. From uncovering the activation of the mTOR pathway in pediatric low-grade gliomas, he went on to conduct successful preclinical studies showcasing the effectiveness of mTOR inhibitors in combination therapy. Now, his research is underpinning a clinical trial to assess the use of Everolimus in pediatric patients facing recurrent or worsening low-grade gliomas.

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Honored Kid Austin while battling acute lymphoblastic leukemia. Right: Austin in 2024, being 10 years cancer-free.

For kids with cancer and their families, clinical trials mean hope – in two ways.

First, phase 1 clinical trials can offer a chance for survival for children with no other viable treatment options.

Second, larger clinical trials help determine whether a new treatment (already tested for safety) offers a better outcome for children than the current standard of care. A better outcome can mean more children cured, or fewer side effects, or a better health outlook for survivors.

With your help, St. Baldrick’s provides crucial support for clinical trials at all stages. Since 2005, more than 145,000 children and teens have been part of a trial supported by St. Baldrick’s donors.

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Something extraordinary began in 2013: the first ever pediatric cancer “Dream Team,” funded by the St. Baldrick’s Foundation and Stand Up to Cancer. Combining genomics and immunotherapy in a way that had not been done before, this team of experts at 8 research institutions across the U.S. and Canada set out to create new therapies for the most challenging childhood cancers.

Because of the incredible strides made by the team, the St. Baldrick’s Foundation and the member institutions continued this work, after the funding from Stand Up to Cancer came to an end in 2018.

Now in its third funding period and with a new name, the EPICC Team (Empowering Pediatric Immunotherapies for Childhood Cancer) continues to be led by John Maris, M.D., and Crystal L. Mackall, M.D., and the discoveries continue, saving lives.

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The St. Baldrick’s Foundation Fellowship award is designed to support the brightest young investigators in the field. This investment of $1.1 million provides support for budding researchers to explore innovative ideas in pediatric cancer research.

Keep scrolling to see the amazing projects your contributions support.

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Our St. Baldrick’s Foundation Research Outcomes blogs highlight examples of the progress your donations are supporting. This quarterly edition focuses on a new FDA approval for neuroblastoma, strategies to improve T cell functioning, understanding why some kids with medulloblastoma get sicker, and how secondary cancers increase the likelihood of future heart problems.

Thank you for making this research possible.

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Where is our very first St. Baldrick’s Fellow now? Still in the lab, that’s where! Meet Dr. Sharon Singh, the physician-scientist who was given the inaugural St. Baldrick’s Fellow Award in 2005. What does that monetary vote of confidence do for a new researcher and for the childhood cancer research field? It’s been 19 years and the results are in – read on to find out.

Dr. Sharon Singh currently works as a clinician, researcher, and associate professor at University of Michigan, C.S. Mott Children’s Hospital.

At the heart of it, Dr. Sharon Singh is a problem solver and for the last decade, the pediatric hematologist-oncologist has been working on the problem of childhood cancer. But she knows that the big problem of kids’ cancer can’t be solved only at the bedside of a patient – problem solvers like her need to be in the lab too.

And that is exactly what Dr. Singh is doing, thanks to a St. Baldrick’s grant given almost 20 years ago.

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Sam playing the cello.

Twenty-year-old Sam is a Renaissance man – an accomplished musician, pilot, and philanthropist. He’s also a three-time shavee, childhood cancer survivor, and 2024 St. Baldrick’s Ambassador who is committed to making a difference in the lives of other kids with cancer.

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We are thrilled to announce $1.1 million in new grants to bolster pediatric cancer clinical trial enrollment. Clinical trials play a crucial role in the fight against childhood cancer. The unsung heroes who help make clinical trials happen for kids are the dedicated clinical research associates, nurses, and support staff.

This $1.1 million supports these necessary roles to ensure more kids get treated on a clinical trial, often their best hope for a cure.

Without your support, these grants would not be possible. Thank you for your generosity and passion to Conquer Kids’ Cancer.

The following institutions were awarded a St. Baldrick’s Foundation Infrastructure award:

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Our St. Baldrick’s Foundation Research Outcomes blogs highlight examples of the progress your donations are supporting. This quarterly edition focuses on promising new treatments for two types of pediatric sarcoma, protecting kids’ brains while treating brain tumors, and the ease of treating retinoblastoma with chemotherapy.

Thank you for making this research possible.

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