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Based on progress to date, Dr. Raabe, the Hannah's Heroes St. Baldrick's Scholar, was awarded a new grant in 2014 to fund an additional two years of this Scholar award. Medulloblastoma is the most common malignant pediatric brain cancer, and patients with high-risk medulloblastoma have a poor prognosis. Unfortunately, few models for aggressive medulloblastoma exist, severely limiting our ability to test new treatments for the patients who need them most. The goal of this proposal is to develop accurate models of high-risk medulloblastoma for pre-clinical therapeutic testing. This allows for rapid progress to be made, as researchers can use these models to screen for new drugs, test drug combinations, identify for factors conferring resistance to chemotherapy, and look for pathways that might be an "Achilles heel" for high-risk medulloblastoma.

This grant is named for the Hannah's Heroes Hero Fund created in honor of Hannah Meeson and pays tribute to her fight by raising awareness and funding for all childhood cancers.