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Shannon Maude M.D., Ph.D.
Funded: 07-01-2013 through 06-30-2018
Funding Type: St. Baldrick's Scholar
Institution Location: Philadelphia, PA
Institution: The Children's Hospital of Philadelphia affiliated with University of Pennsylvania

Based on progress to date, Dr. Maude was awarded new grants in 2016 and 2017 to fund additional years of this Scholar award. Acute lymphoblastic leukemia (ALL), a cancer of white blood cells, is the most common childhood cancer. Fortunately, most children with ALL are cured; however, 10-20% of children are not cured with standard chemotherapy. Recently, genetic tests identified abnormalities that may cause two types of ALL with poor survival rates. Dr. Maude's lab developed models of these leukemias to ask if new medicines that work specifically on the abnormal genes can improve the chance for cure. Dr. Maude, the Rally for Ryan Fund St. Baldrick's Scholar, hopes that these studies will find new treatments for these difficult to treat leukemias, giving these children a new chance for cure. This grant is named for the Rally for Ryan Fund. Ryan was diagnosed with high risk ALL when he was 7 years old. He endured 3 ½ years of often harsh treatments with smiles, laughter and a brave acceptance that this was his fight to win. And Ryan did prevail—he took his last chemo pill in January 2016. This fund honors Ryan’s commitment to help make a difference for kids with cancer by shaving for St. Baldrick’s and raise funds for research.