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Carl Allen M.D., Ph.D.
Funded: 07-01-2017 through 06-30-2018
Funding Type: St. Baldrick's Foundation Innovation Award
Institution Location: Houston, TX
Institution: Baylor College of Medicine affiliated with Texas Children's Hospital, Vannie E. Cook Jr. Children's Cancer and Hematology Clinic

Langerhans Cell Histiocytosis (LCH) is a potentially fatal disease characterized by inflammatory tumors. Recently, researchers discovered that LCH arises from immature immune cells in the blood and is in fact a form of cancer. It is not known why some children develop extensive life-threatening disease, others may have limited tumors, and some develop progressive brain deterioration. In this study, Dr. Allen is investigating the role of inherited genes, acquired gene mutations, and the origin of tumor cells to define the causes of LCH. The ultimate goal is to develop personalized approach to determine the safest, most effective therapy for each child.