Showing 1-2 of 2 results
Kimberly Stegmaier M.D.
Funded: 05-01-2017 through 04-30-2020
Funding Type: Robert J. Arceci Innovation Award
Institution Location: Boston, MA
Institution: Dana-Farber Cancer Institute affiliated with Boston Children's Hospital, Harvard Medical School

While deciphering the genetic code in pediatric cancers has illuminated important insights into their development, for the majority of these children, a matched targeted drug is not revealed. Dr. Stegmaier is working on an alternative solution to identify new, druggable Achilles heels in pediatric cancers. She is systematically eliminating each of 17,500 genes in 100 pediatric cancer cell models with innovative technology to determine whether loss of the gene is lethal. In parallel, Dr. Stegmaier and colleagues are screening these cells with over 4,000 drugs. Novel emerging targets/drugs will be validated in state-of-the-art pediatric cancer models with the ultimate deliverable of new pediatric cancer trials. The St. Baldrick’s Robert J. Arceci Innovation Award is given in honor of the late Dr. Robert Arceci. A pioneer in the field, this award reflects Dr. Arceci’s values including creativity, collaboration, and commitment to early- to mid-career scientists.

Charles G. Mullighan M.D.
Funded: 07-01-2016 through 06-30-2019
Funding Type: Robert J. Arceci Innovation Award
Institution Location: Memphis, TN
Institution: St. Jude Children's Research Hospital

Acute lymphoblastic leukemia is a tumor of white blood cells that normally fight infection. Changes in DNA, or mutations, are important in driving the development of ALL. Mutations in genes that control the reading of DNA are particularly common in leukemia cells that don't respond to treatment. Dr. Mullighan is studying engineered ALL cells and tumors to understand how these mutations result in resistance to therapy, and to develop new ways of treating ALL. The St. Baldrick’s Robert J. Arceci Innovation Award is given in honor of the late Dr. Robert Arceci. A pioneer in the field, this award reflects Dr. Arceci’s values including creativity, collaboration, and commitment to early- to mid-career scientists.