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Late Effects After High Risk Neuroblastoma – The LEAHRN Study Member
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Duarte, CA
Institution: City of Hope

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

Late Effects After High Risk Neuroblastoma – The LEAHRN Study
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Chicago, IL
Institution: The University of Chicago affiliated with Comer Children's Hospital

Modern therapies such as stem cell transplant and immune therapy have made high-risk neuroblastoma a survivable disease for some children, but little is known about the chronic health issues experienced by survivors. In order to ensure that future treatments address both the chance and the quality of cure, this consortium aims to examine the impact of neuroblastoma therapy on survivors' growth, pubertal development and long-term health. This grant is generously supported by the "Just Do It...…and be done with it" Hero Fund created in honor of Sara Martorano who doesn't let anything dim her sparkle and has a compassionate heart and smile. It also celebrates the courage of all cancer kids through treatment and the support of their family and friends.

Late Effects After High Risk Neuroblastoma – The LEAHRN Study Member
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Boston, MA
Institution: Dana-Farber Cancer Institute affiliated with Boston Children's Hospital, Harvard Medical School

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

Andrew Smitherman M.D.
Funded: 07-01-2015 through 06-30-2017
Funding Type: St. Baldrick's Fellow
Institution Location: Chapel Hill, NC
Institution: University of North Carolina at Chapel Hill affiliated with UNC Children's Hospital

Most childhood cancer survivors develop complications associated with their treatment and many will require hospitalization. Dr. Smitherman is working to determine how often survivors are seen in an emergency department or hospitalized in the first years following completion of treatment. This research is also reviewing which medications are prescribed during this time to better understand what medical complications survivors are experiencing. With this knowledge, Dr. Smitherman hopes to prevent complications and improve survivors' quality of life.

Jonathan Posner M.D.
Funded: 07-01-2015 through 02-28-2018
Funding Type: Supportive Care Research Grant
Institution Location: New York, NY
Institution: Columbia University Medical Center affiliated with Morgan Stanley Children’s Hospital, New York-Presbyterian

Survivors of pediatric brain tumors commonly struggle with progressive declines in attention and memory that emerge following neurosurgery, chemotherapy and radiation. Unfortunately, little is known about the neurobiological substrates of these cognitive dysfunctions. Dr. Posner's Grace for Good St. Baldrick’s Supportive Care Grant aims to identify the specific changes in functional and structural brain connectivity that correlate with neurocognitive decline by collecting advanced magnetic resonance imaging (MRI) and neuropsychological test data on survivors. This data is being compared with healthy controls across three academic medical centers: Columbia University Medical Center, Children’s Medical Center-Dallas and Seattle Children’s Hospital. This grant is named for the Grace for Good Fund created in honor of Grace Carey, a medulloblastoma survivor. It supports research of brain tumors and survivorship issues in the hopes of changing kids’ lives for good.

Late Effects After High Risk Neuroblastoma – The LEAHRN Study Member
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Toronto, ON
Institution: Hospital for Sick Children

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

Late Effects After High Risk Neuroblastoma – The LEAHRN Study Member
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Philadelphia, PA
Institution: The Children's Hospital of Philadelphia affiliated with University of Pennsylvania

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

Lisa Schwartz Ph.D.
Funded: 07-01-2015 through 06-30-2018
Funding Type: Supportive Care Research Grant
Institution Location: Philadelphia, PA
Institution: The Children's Hospital of Philadelphia affiliated with University of Pennsylvania

Adolescents and young adults with cancer do not receive adequate support and face a higher rate of relapse relative to younger patients. Dr. Schwartz's project is taking a current texting intervention which aims to improve health-related knowledge and engagement, and upgrading the technology and content in order to maximize the impact. This research aims to ultimately help improve the health and well-being of adolescents and young adults with cancer.

Nickhill Bhakta M.D.
Funded: 07-01-2015 through 06-30-2018
Funding Type: St. Baldrick's Fellow
Institution Location: Memphis, TN
Institution: St. Jude Children's Research Hospital

Based on progress to date, Dr. Bhakta was awarded a new grant in 2017 to fund an additional year of this Fellow award. While the increase cure rates for many childhood cancers is cause for celebration, researchers are increasingly recognizing the long-term consequences of cancer therapy. Recent studies have shown that survivors of childhood cancer are at risk for developing a wide range of long-term health problems and die at an earlier age due to the lifelong side effects of their curative therapies. Dr. Bhakta is investigating the magnitude of chronic health conditions experienced by survivors to inform future approaches for prevention and early detection to maximize long-term survival and quality of life. A portion of the grant was generously supported by the Morgan and Friends Fund created to honor Morgan Loudon and celebrate her strength and determination as a cancer survivor while rallying family and friends to “battle on” in the search for cures and better treatments.

Tara Brinkman Ph.D.
Funded: 07-01-2015 through 06-30-2018
Funding Type: St. Baldrick's Scholar
Institution Location: Memphis, TN
Institution: St. Jude Children's Research Hospital

Survivors of childhood brain tumors are at-risk for problems with developing social relationships. These problems can lead to feelings of isolation, loneliness and social anxiety. Dr. Brinkman believes this is due to changes in a survivor's brain due to their cancer and its treatment. Dr. Brinkman's research aims to examine how the structure and function of the brain is related to survivors’ understanding of social information and their social behavior. These results aim to help with the identification of treatments for social problems.

Late Effects After High Risk Neuroblastoma – The LEAHRN Study Member
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Memphis, TN
Institution: St. Jude Children's Research Hospital

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

Late Effects After High Risk Neuroblastoma – The LEAHRN Study Member
Funded: 07-01-2015 through 06-30-2018
Funding Type: Consortium Research Grant
Institution Location: Seattle, WA
Institution: Seattle Children's Hospital affiliated with Fred Hutchinson Cancer Research Center, University of Washington

This institution is a member of a research consortium which is being funded by St. Baldrick's: Late Effects After High Risk Neuroblastoma – The LEAHRN Study. For a description of this project, see the consortium grant made to the lead institution: University of Chicago, Chicago, IL

Jason Mendoza M.D., M.P.H.
Funded: 07-01-2015 through 06-30-2017
Funding Type: Supportive Care Research Grant
Institution Location: Seattle, WA
Institution: Seattle Children's Hospital affiliated with Fred Hutchinson Cancer Research Center, University of Washington

By increasing physical activity, survivors may reduce their risk of obesity and chronic diseases, and improve their quality of life. Dr. Mendoza's research aims to examine the use of a wearable physical activity device, the Fitbit, paired with a Facebook group, to increase physical activity among teen childhood cancer survivors. This approach aims to harness new wearable technology and the widespread use of smart phones to use individual- and peer-influences to promote physical activity.

Amanda Termuhlen M.D.
Funded: 01-01-2015 through 12-31-2015
Funding Type: Infrastructure Grant
Institution Location: Long Beach, CA
Institution: Miller Children's Hospital affiliated with Harbor-UCLA Medical Center, Jonathan Jaques Children's Cancer Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

This grant helps provide necessary resources for the Survivors’ Treatment Assessment and Resource (STAR) program at this institution, enhancing research while providing childhood cancer survivors the support, treatment and education they need to prevent and address late effects.

Birte Wistinghausen M.D.
Funded: 01-01-2015 through 12-31-2016
Funding Type: Infrastructure Grant
Institution Location: New York, NY
Institution: Ichan School of Medicine at Mount Sinai affiliated with Kravis Children’s Hospital at Mount Sinai

This grant helps provide necessary resources for the Long Term Follow-up Program at this institution, enhancing research while providing childhood cancer survivors the support, treatment and education they need to prevent and address late effects.

Laura Hogan M.D.
Funded: 01-01-2015 through 12-31-2015
Funding Type: Infrastructure Grant
Institution Location: Stony Brook, NY
Institution: Stony Brook University affiliated with Stony Brook Long Island Children's Hospital

This grant helps provide necessary resources to support the Survivorship Clinic, and to study, through increased clinical trial enrollment, the late effects of recently treated children.

John Gates M.D.
Funded: 12-01-2014 through 11-30-2016
Funding Type: Infrastructure Grant
Institution Location: Madera, CA
Institution: Valley Children's Healthcare

This grant helps provide necessary resources for the Childhood Cancer Survivorship Program at this institution, enhancing research while providing childhood cancer survivors the support, treatment and education they need to prevent and address late effects.

Gregory Aune M.D., Ph.D.
Funded: 09-01-2014 through 08-31-2018
Funding Type: St. Baldrick's Scholar
Institution Location: San Antonio, TX
Institution: University of Texas Health Science Center at San Antonio

Based on progress to date, Dr. Aune was awarded a new grant in 2017 to fund an additional year of this Scholar award. Survival from pediatric cancer approaches 80%, but long-term survivors have alarming rates of heart disease as adults. Dr. Aune's lab has developed models to study how pediatric cancer therapies affect the heart. This research aims to determine the potential for new chemotherapy agents to damage the heart. These strategies will lead to a better quality of life for children who survive cancer.

Jeffrey Lukish M.D.
Funded: 07-01-2014 through 06-30-2015
Funding Type: Supportive Care Research Grant
Institution Location: Baltimore, MD
Institution: Johns Hopkins University School of Medicine affiliated with Johns Hopkins Children's Center

Most children treated for cancer can now expect to be cured. However, in a significant majority, future fertility may be compromised by their disease or its treatment. Girls are particularly at risk to ovarian injury. These children are cured; however the girls will live the rest of their life in menopause and they will also sadly be unable to have a child of their own. Dr. Lukish's work aims to open the field of ovarian cryopreservation in children by providing an evidence base for future practice, with significant potential benefit to young girls with cancer.

Kristen Hoskinson Ph.D.
Funded: 07-01-2014 through 06-30-2018
Funding Type: Supportive Care Research Grant
Institution Location: Columbus, OH
Institution: The Research Institute at Nationwide affiliated with Nationwide Children's Hospital

Although most kids with a brain tumor survive the tumor itself, many have trouble doing activities that require attention and memory, and they often have difficulty fitting in with peers. Both types of difficulty could be related to changes in their brain structure or function, but research on this hasn'’t been done yet. Dr. Hoskinson is looking at whether there's a connection between these changes in brain structure and function and how kids get along with their peers. If there is, this research aims to help predict which kids will have social problems after treatment and identify ways to help.