Showing 1-20 of 382 results
Kelly Faulk M.D.
Funded: 07-01-2018 through 06-30-2020
Funding Type: St. Baldrick's Fellow
Institution Location: Denver, CO
Institution: University of Colorado affiliated with Children's Hospital Colorado

Leukemia is a cancer of blood cells that can be caused by a variety of genetic changes. The leukemia cells of some children have a genetic change in which a gene (KMT2A) is broken and combined with other genes that typically do not interact with one another (this is called "rearranged"). This genetic rearrangement then alters how other genes are turned on or off in the cell, turning on genes that drive the development of leukemia. This leukemia can be seen in all ages but is most common in infants. Unfortunately, it is a very aggressive leukemia with a high risk of relapse and poor overall survival. A drug named pinometostat has been developed that directly targets the underlying changes that occur with this genetic rearrangement and specifically kills these leukemia cells. When pinometostat was tested by itself in these leukemia patients, it was proven safe and showed killing of leukemia cells in some patients. Dr. Faulk and colleagues have developed a new clinical trial that combines pinometostat with standard chemotherapy for kids and young adults with relapsed or resistant leukemia with a KMT2A gene rearrangement. This trial is testing the safety of pinometostat when it is given with other chemotherapy medicines, seeing how the drug is broken down by the body, and determining how the drug affects the body. The trial is also determining if pinometostat works better to fight cancer when given with other chemotherapy rather than alone. If proven safe, the drug may then continue in further testing to better understand how effective it is in this type of leukemia. The long-term goal is to improve the cure rate for this group of high-risk leukemia patients and provide these children with more treatment options that they urgently need.

Hector Rodriguez Cortes M.D.
Funded: 05-01-2018 through 04-30-2019
Funding Type: Infrastructure Grant
Institution Location: Ft. Lauderdale, FL
Institution: Broward General Medical Center

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Alex Kentsis M.D., Ph.D.
Funded: 03-01-2018 through 02-28-2021
Funding Type: Robert J. Arceci Innovation Award
Institution Location: New York, NY
Institution: Memorial Sloan Kettering Cancer Center

Dr. Kentsis is working to advance both our basic scientific knowledge about how young people develop cancer, and to use that knowledge to discover and develop new treatments for children that are precise, curative and safe. The St. Baldrick’s Robert J. Arceci Innovation Award is given in honor of the late Dr. Robert Arceci. A pioneer in the field, this award reflects Dr. Arceci’s values including creativity, collaboration, and commitment to early- to mid-career scientists.

Carl Allen M.D., Ph.D.
Funded: 03-01-2018 through 02-28-2019
Funding Type: St. Baldrick's Foundation Innovation Award
Institution Location: Houston, TX
Institution: Baylor College of Medicine affiliated with Texas Children's Hospital, Vannie E. Cook Jr. Children's Cancer and Hematology Clinic

Langerhans Cell Histiocytosis (LCH) is a potentially fatal disease characterized by inflammatory tumors. Recently, researchers discovered that LCH arises from immature immune cells in the blood and is in fact a form of cancer. It is not known why some children develop extensive life-threatening disease, others may have limited tumors, and some develop progressive brain deterioration. In this study, Dr. Allen is investigating the role of inherited genes, acquired gene mutations, and the origin of tumor cells to define the causes of LCH. The ultimate goal is to develop personalized approach to determine the safest, most effective therapy for each child.

Albert Kheradpour M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Loma Linda, CA
Institution: Loma Linda University

This grant supports a Clinical Research Coordinator to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Jacqueline Casillas M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Long Beach, CA
Institution: Jonathan Jaques Children's Cancer Center affiliated with Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), Miller Children's Hospital

This grant supports the efforts to translate clinical trial materials to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Don Eslin M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Orlando, FL
Institution: Arnold Palmer Hospital for Children

This grant supports a Clinical Research Coordinator to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Ann Mertens Ph.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Atlanta, GA
Institution: Children's Healthcare of Atlanta affiliated with Aflac Cancer Center, Emory University

This grant supports a clinical research protocol writer to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Varun Monga M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Iowa City, IA
Institution: University of Iowa Hospitals & Clinics affiliated with University of Iowa Children's Hospital

Cancer treatment outcomes in patients between ages 13-39 years (adolescent and young adults - AYA) have been quite dismal. Clinical trials are cancer treatment options which potentially offers newer drugs in the hopes to cure cancer. One of the reasons for poor outcomes is limited participation of AYA cancer patients in clinical trials. This grant supports a Clinical Research Coordinator to ensure that more adolescent and young adults can be treated on clinical trials, often their best hope for a cure.

Nobuko Hijiya M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Chicago, IL
Institution: Ann & Robert H. Lurie Children's Hospital affiliated with Northwestern University

This grant supports a Clinical Research Coordinator to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Peter Newburger M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Worcester, MA
Institution: University of Massachusetts

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Karim Sadak M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Minneapolis, MN
Institution: University of Minnesota - Twin Cities affiliated with Masonic Children's Hospital

This grant supports a Clinical Research Associate to support the childhood Cancer Survivor Program (cCSP) and ensure that more kids can be treated on clinical trials, often their best hope for a cure.

William S. Ferguson M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: St. Louis, MO
Institution: SSM Cardinal Glennon Children's Hospital affiliated with Saint Louis University

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Koh Boayue M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Albuquerque, NM
Institution: University of New Mexico Health Sciences Center affiliated with UNM Children's Hospital

This grant supports clinical research staff to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Mahmut Celiker M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Brooklyn, NY
Institution: Maimonides Medical Center

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure. Maimonides Medical Center is the only designated cancer center in Brooklyn, NY, home to over 600,000 children, two-thirds of whom are minorities.

Laura Hogan M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Stony Brook, NY
Institution: Stony Brook University affiliated with Stony Brook Long Island Children's Hospital

This grant supports a Nurse Navigator for adolescents and young adults at Stony Brook Cancer Center, with a particular focus on increased clinical trial enrollment.

Steven Kuerbitz M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Akron, OH
Institution: Akron Children's Hospital

This grant supports a Clinical Research Associate to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

William H. Meyer M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Oklahoma City, OK
Institution: University of Oklahoma Health Sciences Center affiliated with The Children's Hospital at OU Medical Center

This grant supports clinical research staff to ensure that more kids can be treated on clinical trials, often their best hope for a cure.

Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Ft. Worth, TX
Institution: Cook Children's Medical Center

This grant supports a Research Coordinator for the Targeted Therapeutics program, to ensure that more kids can be treated on targeted genomic clinical trials, which have not been widely available in North and West Texas.

Eric Lowe M.D.
Funded: 01-01-2018 through 12-31-2018
Funding Type: Infrastructure Grant
Institution Location: Norfolk, VA
Institution: Children's Hospital of The King's Daughters affiliated with Eastern Virginia Medical School

This grant supports clinical research staff to ensure that more kids can be treated on clinical trials, often their best hope for a cure.