When people come together for a cause, incredible things happen. That’s true for St. Baldrick’s head-shaving events AND for the lifesaving work done by St. Baldrick’s researchers, especially the Stand Up To Cancer - St. Baldrick’s Pediatric Dream Team. As they say, teamwork makes the dream work! Read on to learn more about how cooperation and sharing between these researchers means big advances for kids with cancer.
They say two heads are better than one. But what about 149? That is how many brilliant brains are working together to conquer childhood cancers as part of the SU2C – St. Baldrick’s Pediatric Cancer Dream Team.
And it’s that cooperation that’s accelerating progress for kids and laying the foundation for better treatments and for cures, said Dr. Crystal Mackall and Dr. John Maris, co-leaders of the Dream Team.
Instead of being bound to a specific project, researchers who receive the Robert J. Arceci Innovation Award are given the resources and the freedom to go wherever their curiosity, pioneering spirit, and passion for kids’ cancer research takes them — and the newest awardee, London’s Dr. Sam Behjati, has those three characteristics in spades. Read on (and watch the video!) for more about this innovative award and its first international winner.
Where do cancer tumors come from?
That is the question that gets Dr. Sam Behjati’s gears turning. It keeps the researcher combing through genes in his lab near London. It’s the question he wants to answer to help kids with cancer.
And as the first international winner of the Robert J. Arceci Innovation Award, it’s a question Dr. Behjati can now explore freely — wherever it may take him.
The review took place at The Children’s Hospital of Philadelphia (CHOP), and reporting for the Dream Team were co-leaders Dr. John M. Maris, director of the Center for Childhood Cancer Research at CHOP, and Dr. Crystal Mackall, chief of the Pediatric Oncology Branch of the National Cancer Institute (NCI).
The review panel included representatives from Stand Up to Cancer (SU2C), our partner in making this $14.5 million grant; the American Association for Cancer Research (AACR); and of course St. Baldrick’s.
I am excited to report that this Dream Team seems to be making more rapid progress than most. This is partly due to the fact that researchers in childhood cancer are more accustomed to working with colleagues from multiple institutions than are researchers in the adult oncology world.
Dr. Parsons, a genomics expert on the Stand Up To Cancer – St. Baldrick’s Pediatric Cancer Dream Team.
For example, we know that childhood cancer is caused by genetic mutations. What we don’t know is how or why most of those mutations occur.
And we’re still trying to figure out what the mutations mean — in terms of the cancer and its ability to thrive, and in terms of our bodies and their ability to overcome disease.
That’s the focus of genomics, explains Dr. Donald Parsons, the principal investigator at Baylor College of Medicine for the Stand Up To Cancer – St. Baldrick’s Pediatric Cancer Dream Team.
“Genomics is the study on a large scale of all the genetic changes that occur in a patient’s DNA,” Dr. Parsons says. “It really tries to look at — in a single patient or across a group of patients — all the different changes that occur and how they might interact with each other.”
Dr. Choo is also a St. Baldrick’s Fellow, having received a two-year, $123,149 grant for her pediatric oncology research focused on Ewing sarcoma, a bone and soft tissue cancer that occurs in adolescents and young adults.