Facts

Types of Childhood Cancer: Juvenile Myelomonocytic Leukemia (JMML)

by Elliot Stieglitz, M.D.
March 14, 2016

Dr. Elliot Stieglitz is a St. Baldrick’s Fellow at the University of California, San Francisco. He’s researching ways to help kids with JMML who don’t respond to standard treatment. He explains JMML symptoms, treatment options, and how your support is moving research forward.

What is JMML

What is JMML?

Juvenile myelomonocytic leukemia (JMML) is a type of blood cancer that affects young children.

The average age at diagnosis is around 2 years old, although some children are found to have JMML just days after being born.

It is an extremely rare disease with approximately 50 new cases occurring in the United States each year.

What are the signs and symptoms of JMML?

What is JMML

JMML cells seen in lung tissue. Photo via UCSF Department of Pathology.

JMML cells develop in the bone marrow and circulate in the blood. Often, these cancer cells enter organs in the body and cause certain symptoms:

  • JMML cells can crowd the spleen and liver, leading to swelling of the abdomen. This can put pressure on the stomach and cause children to gain weight more slowly than usual.
  • If leukemia cells enter the lungs, children may have shortness of breath or difficulty breathing.
  • Fever, lack of energy, bleeding and rashes are also common symptoms.

How is JMML diagnosed?

The first step is to look at a blood sample under a microscope. All children suspected of having JMML will need a bone marrow biopsy in order to ensure that they do not have another type of leukemia.

Learn more about childhood cancer >

Certain changes in DNA, also called “mutations,” are found in 90% of children with JMML. Doctors can identify these mutations by reading the letters of DNA inside the leukemia in a process called “DNA sequencing.” This can help them make the diagnosis of JMML.

What treatment options are available for patients with JMML?

The only curative treatment for JMML is a stem cell transplant. It often takes several months to find a potential donor to provide these cells. Most patients are prescribed chemotherapy while waiting for a transplant.

Very rarely, a small percentage of patients with JMML have had their leukemia go into remission without any treatment. Unfortunately, we cannot predict at diagnosis which patients will fall into this category.

Read about Caemon and his JMML story >

How is research helping children with JMML?

Over the past two decades, researchers have identified several mutations that allow for a more rapid diagnosis. In addition, researchers have shown that nearly 25% of patients with JMML have syndromes that make developing JMML more likely, including neurofibromatosis type 1 (NF1) and CBL syndrome.

Treatment with a stem cell transplant has also become much safer thanks to advances in clinical research. Still, only about 50% of kids with JMML survive five years beyond diagnosis. Researchers are currently working to learn more about JMML to develop better treatments to improve survival for kids with JMML.

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