Showing 1-20 of 1482 results
Reshmi Parameswaran Ph.D
Funded: 09-01-2016 through 08-31-2019
Funding Type: St. Baldrick's Scholar
Institution Location: Cleveland, OH
Institution: Case Western Reserve University

Acute Myeloid Leukemia (AML) is the second most common acute leukemia in children, and current treatment strategies are inadequate to cure AML. Dr. Parameswaran is developing a new strategy using Natural Killer cells, which are a type of white blood cells with potential to kill cancer cells. Cancer cells often produce a protein that makes Natural Killer cells less active, which helps the cancer cells escape from NK cell-mediated killing. Dr. Parameswaran and his team are developing methods to stop this NK cell inactivation and thereby improve NK cell function to treat pediatric AML.

Le Su Ph.D.
Funded: 07-01-2016 through 06-30-2017
Funding Type: Research Grant
Institution Location: Huntsville, AL
Institution: HudsonAlpha Institute for Biotechnology

Genes instruct cells to do their jobs through making specific proteins. In the human body, all cells store these "instructions" in the chromosomes. When chromosomes break off, the broken pieces sometimes change places and create new chromosomes. These changes are called chromosomal translocations. Dr. Su is studying how chromosomal translocations cause deadly diseases in children and young adults, and more importantly, is investigating possible clinical options to correct these abnormal conditions.

Treehouse Childhood Cancer Initiative Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: Vancouver, BC
Institution: British Columbia Cancer Agency affiliated with British Columbia Children's Hospital, The University of British Columbia

This institution is a member of a research consortium which is being funded by St. Baldrick's: Treehouse Childhood Cancer Initiative. For a description of this project, see the consortium grant made to the lead institution: University of California Santa Cruz, Santa Cruz, CA.

Treehouse Childhood Cancer Initiative Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: Vancouver, BC
Institution: British Columbia Children's Hospital affiliated with British Columbia Cancer Agency, The University of British Columbia

This institution is a member of a research consortium which is being funded by St. Baldrick's: Treehouse Childhood Cancer Initiative. For a description of this project, see the consortium grant made to the lead institution: University of California Santa Cruz, Santa Cruz, CA.

Anne Barasa MBChB, MMed
Funded: 07-01-2016 through 06-30-2019
Funding Type: International Scholar
Institution Location: Duarte, CA
Institution: Beckman Research Institute of the City of Hope

Kaposi sarcoma (KS) is the most common cancer among persons living with HIV in sub-Saharan Africa, and the incidence and mortality rates of pediatric Kaposi sarcoma have risen dramatically as a result of the HIV/AIDS epidemic. The diagnosis and treatment of KS in low resource settings, particularly in children, is very challenging. Dr. Barasa, an international scholar from Kenya, is developing and testing a subunit vaccine candidate with an outstanding potential to weaken Kaposi sarcoma-associated herpesvirus infection, which, if successful, will lead to an effective vaccine capable of preventing and treating KS in children.

Robert Wechsler-Reya Ph.D.
Funded: 07-01-2016 through 06-30-2017
Funding Type: Research Grant
Institution Location: La Jolla, CA
Institution: Sanford-Burnham Medical Research Institute

Medulloblastoma (MB) is a highly aggressive pediatric brain tumor for which safer and more effective therapies are needed. Recent studies have identified four major forms of MB that differ in terms of molecular characteristics and patient outcomes. Dr. Wechsler-Reya is working to identify genes that drive Group 4 MB tumor formation, the most prevalent form of MB, to develop new strategies for treatment of this devastating disease.

Yong-Mi Kim M.D., Ph.D., M.P.H. 
Funded: 07-01-2016 through 06-30-2017
Funding Type: Research Grant
Institution Location: Los Angeles, CA
Institution: Children's Hospital Los Angeles

Drug resistance remains a major obstacle in acute lymphoblastic leukemia (ALL). Instead of targeting only the leukemia cells, Dr. Kim is studying the protective non-leukemia cells that are located in the bone marrow, creating a safe haven for drug-resistant ALL cells. Dr. Kim's team has identified a molecule in leukemia cells that allows leukemia cells to remain in the bone marrow and shelters them from the otherwise toxic effects of chemotherapy. Dr. Kim's Johnny Crisstopher Children’s Charitable Foundation St. Baldrick’s Research Grant is testing a novel inhibitor of this molecule to overcome drug resistance. The mission of the Johnny Crisstopher Children's Charitable Foundation is to raise awareness of pediatric cancer and provide funds for research, treatment, and - ultimately - a cure. Famed illusionist Criss Angel founded the foundation in 2008 for charitable causes but it has now become his life's mission since his son, Johnny Crisstopher was diagnosed with leukemia in 2015 at 20 months old.

Yves DeClerck M.D.
Funded: 07-01-2016 through 06-30-2017
Funding Type: Research Grant
Institution Location: Los Angeles, CA
Institution: Children's Hospital Los Angeles

Neuroblastoma is the second most common solid tumor in children, and is a cancer that frequently metastasizes to the bone marrow. Dr. DeClerck is studying how neuroblastoma cells "teach" bone marrow cells to promote tumor growth.

Treehouse Childhood Cancer Initiative Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: Orange, CA
Institution: Children's Hospital of Orange County

This institution is a member of a research consortium which is being funded by St. Baldrick's: Treehouse Childhood Cancer Initiative. For a description of this project, see the consortium grant made to the lead institution: University of California Santa Cruz, Santa Cruz, CA.

Liora Schultz M.D.
Funded: 07-01-2016 through 06-30-2019
Funding Type: St. Baldrick's Scholar
Institution Location: Palo Alto, CA
Institution: Stanford University affiliated with Lucile Packard Children’s Hospital

The human immune system is made up of a complicated network of cells including cells that help fight diseases such as cancer, and cells that prevent the immune system from fighting disease. Key cells that stop immune fighter cells from destroying cancer are called T regulatory cells (Tregs). Dr. Schultz is studying a new way to stop these Tregs and allow the good fighter cells to resume their ability to destroy cancer cells. This therapy will allow immune cells to put up a stronger fight against cancer and lead patients with cancer closer to cure.

Treehouse Childhood Cancer Initiative Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: Palo Alto, CA
Institution: Stanford University affiliated with Lucile Packard Children’s Hospital

This institution is a member of a research consortium which is being funded by St. Baldrick's: Treehouse Childhood Cancer Initiative. For a description of this project, see the consortium grant made to the lead institution: University of California Santa Cruz, Santa Cruz, CA.

Melissa Mavers M.D., Ph.D.
Funded: 07-01-2016 through 06-30-2018
Funding Type: St. Baldrick's Fellow
Institution Location: Palo Alto, CA
Institution: Stanford University affiliated with Lucile Packard Children’s Hospital

Many children with cancer cannot be cured with chemotherapy alone and must undergo bone marrow transplantation. This treatment permits very high doses of chemotherapy to cure the cancer then rebuilds the immune system, which is destroyed by such high chemotherapy doses. In many cases, rebuilding a new immune system causes the new immune cells to attack the body, which is called graft-versus-host disease. Graft-versus-host disease can damage many organs. Dr. Mavers is studying ways to use special cell types to stop graft-versus-host disease and make stem cell transplantation a safer way to cure cancer. This is made with generous support from the Rays of Hope Hero Fund that honors the memory of Rayanna Marrero by giving hope through research funding. She is remembered for her infectious smile and energetic spirit that continue to inspire so many.

Treehouse Childhood Cancer Initiative Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: San Francisco, CA
Institution: University of California, San Francisco affiliated with UCSF Benioff Children's Hospital

This institution is a member of a research consortium which is being funded by St. Baldrick's: Treehouse Childhood Cancer Initiative. For a description of this project, see the consortium grant made to the lead institution: University of California Santa Cruz, Santa Cruz, CA.

Pediatric LEukemiA Precision-based Therapy (LEAP) Consortium Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: San Francisco, CA
Institution: University of California, San Francisco affiliated with UCSF Benioff Children's Hospital

This institution is a member of a research consortium which is being funded by St. Baldrick's: Pediatric LEukemiA Precision-based Therapy (LEAP) Consortium. For a description of this project, see the consortium grant made to the lead institution: Dana-Farber Cancer Institute, Boston, MA.

Benjamin Huang M.D.
Funded: 07-01-2016 through 06-30-2018
Funding Type: St. Baldrick's Fellow
Institution Location: San Francisco, CA
Institution: University of California, San Francisco affiliated with UCSF Benioff Children's Hospital

Cure rates for Acute myeloid leukemia (AML) are poor and current therapies are toxic. Dr. Huang is using accurate models of AML to test novel agents that target cancer specific dependences. The overall goal of Dr. Huang's research is to develop new therapeutic strategies in AML to enhance efficacy and reduce toxicity. This research will inform efforts to develop novel treatment combinations in children with AML.

William Weiss M.D., Ph.D. 
Funded: 07-01-2016 through 06-30-2017
Funding Type: Research Grant
Institution Location: San Francisco, CA
Institution: University of California, San Francisco affiliated with UCSF Benioff Children's Hospital

Targeted therapy works by attacking an abnormal gene product that is specific to the cancer type. Only a minority of neuroblastoma types show genetic drivers, which makes it difficult to develop targeted therapy. Most neuroblastomas show too many or too few copies of large chromosomal regions, called CNAs. Dr. Weiss is studying the connection between CNAs and neuroblastoma, to determine if it CNA is a possible candidate for targeted therapy. Dr. Weiss is engineering CNAs to create CNA-driven models of neuroblastoma, which he will then use to identify CNA-specific therapies to treat neuroblastoma.

Treehouse Childhood Cancer Initiative
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: Santa Cruz, CA
Institution: University of California, Santa Cruz

Cancer is a genetic disease caused by errors in the genomic content of tumor cells. This consortium shares, in real-time, pediatric cancer data generated by genomic studies across the world, uniting data on a variety of cancer types from diverse sources into a compendium of unprecedented scale. The consortium uses the collected data to analyze each child's cancer data against both childhood and adult patient cohorts across all types of cancer, so that this information can be used for clinical decision-making. The research team has evidence that this cross-cancer analysis can identify situations where a drug developed for another indication may work in a pediatric cancer, providing new treatment avenues and new hope to children with cancer and their families. Funds administered by University of California Santa Cruz.

Pediatric LEukemiA Precision-based Therapy (LEAP) Consortium Member
Funded: 07-01-2016 through 06-30-2017
Funding Type: Consortium Research Grant
Institution Location: Denver, CO
Institution: University of Colorado affiliated with Children's Hospital Colorado

This institution is a member of a research consortium which is being funded by St. Baldrick's: Pediatric LEukemiA Precision-based Therapy (LEAP) Consortium. For a description of this project, see the consortium grant made to the lead institution: Dana-Farber Cancer Institute, Boston, MA.

James DeGregori Ph.D.
Funded: 07-01-2016 through 06-30-2017
Funding Type: Research Grant
Institution Location: Denver, CO
Institution: University of Colorado affiliated with Children's Hospital Colorado

Progress in improving therapy for Acute myeloid leukemia (AML) has been slow and survival rates for patients remain quite low. Thus, there is a great need for more effective and less toxic therapies for AML. Dr. DeGregori has identified a new molecule called MCJ, the loss of which is associated with the resistance of cancers to therapies. Dr. DeGregori has developed novel drugs that can restore MCJ function in cancer cells, and is investigating whether these MCJ activating drugs can be used improve therapies for AML.

Yale School of Medicine Summer Fellow
Funded: 07-01-2016 through 08-31-2016
Funding Type: St. Baldrick's Summer Fellow
Institution Location: New Haven, CT
Institution: Yale University affiliated with Yale-New Haven Children's Hospital

This grant funds a doctoral student to complete work in pediatric oncology research for the summer. The experience may encourage them to choose childhood cancer research as a specialty.